The name of your medicine is ‘Paludrine/Avloclor Anti-malarial Travel Pack’. It is referred to as ‘Anti-malarial Travel Pack’ in the rest of this leaflet.
Your Paludrine Avloclor Anti-malarial Travel Pack contains two types of tablets:
Both medicines belong to a group of medicines called ‘antimalarial’.
Antimalarial drugs can be used in certain parts of the world to help prevent malaria. This is a serious disease spread by infected mosquitoes. Your Anti-malarial Travel Pack will give some degree of protection (prophylaxis) against malaria in certain countries. It can be used when it is necessary to take more than one type of medicine at the same time to help prevent malaria.
Medicines to help prevent malaria (malaria prophylaxis) are recommended for:
These people have little or no immunity to malaria, so they are at risk of severe attacks.
You must get medical advice on which anti-malarial medicines to take.
You must ask your doctor or pharmacist if this Anti-malarial Travel Pack is suitable for the part of the world that you are visiting.
Avoiding mosquito bites
When you are taking this medicine to prevent malaria, you should also reduce the chances of being bitten by mosquitoes.
If you have a high temperature
No medicine can be guaranteed to protect against malaria in every case. If you have a high temperature (fever) during your visit to a malaria area, or up to a year after returning home, you should suspect malaria. Contact a doctor straight away and let him or her know that you have visited a malaria area.
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Avoiding mosquito bites
When you are taking this medicine to prevent malaria, you should also reduce the chances of being bitten by mosquitoes.If you have a high temperature
No medicine can be guaranteed to protect against malaria in every case. If you have a high temperature (fever) during your visit to a malaria area, or up to a year after returning home, you should suspect malaria. Contact a doctor straight away and let him or her know that you have visited a malaria area.Antimalarial drugs, Paludrine / Avloclor, can be used in certain parts of the world to help prevent malaria. This is a serious disease spread by infected mosquitoes. Your Anti-malarial Travel Pack will give some degree of protection (prophylaxis) against malaria in certain countries.
How to use your Anti-malarial Travel Pack
If this medicine is from your doctor or pharmacist, take it exactly as they have told you. Otherwise, follow the instructions below. If you do not understand the instructions, or you are not sure, ask your doctor or pharmacist.
When to start taking your medicine
Adults and children over 14 years
Children
Do not use this Anti-malarial Travel Pack in children under 1 year of age. For children over 1 year of age, the dose depends on the child’s age.
How to take your tablets
If you take more Paludrine or Avloclor tablets than you should
If you accidentally take more Paludrine or Avloclor tablets than you should, tell a doctor straight away. Show any left-over medicines or the empty packet to the doctor. The following effects may happen if you take more Avloclor tablets than you should: heart problems – leading to uneven heart beats.
If you forget to take your Paludrine tablets
If you forget to take your Avloclor tablets
Stopping your Anti-malarial Travel Pack
Only stop using your Anti-malarial Travel Pack four weeks after leaving the malaria area or if your doctor tells you to.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
What you need to know before you use your Anti-malarial Travel Pack
Do not use this Anti-malarial Travel Pack if:
Warnings and precautions
Check with your doctor or pharmacist before taking your medicine if:
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before using your Anti-malarial Travel Pack.
Chloroquine can cause lowering of the blood glucose level. Please ask your doctor to inform you of signs and symptoms of low blood glucose levels. A check of the blood glucose level may be necessary.
Chloroquine may cause heart rhythm disorders in some patients: caution should be taken when using chloroquine, if you were born with or have family history of prolonged QT interval, if you have acquired QT prolongation (seen on ECG, electrical recording of the heart), if you have heart disorders or have a history of heart attack (myocardial infarction), if you have salt imbalance in the blood (especially low level of potassium or magnesium, see section “Other medicines and your Anti-malarial Travel Pack”).
If you experience palpitations or irregular heart beat during the period of treatment, you should inform your doctor immediately. The risk of heart problems may increase with increase of the dose. Therefore, the recommended dosage should be followed.
If you go into hospital, tell the medical staff that you are taking both Paludrine and Avloclor.
If you live in a country where malaria occurs, you may already be slightly immune to the disease. You must ask a doctor or pharmacist for advice before you take anti-malarial medicines.
Other medicines and your Anti-malarial Travel Pack
Please tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines. This includes medicines that you buy without a prescription and herbal medicines.
Amiodarone (used to control heart rate) must not be taken at the same time as Avloclor (see section 2: What you need to know before you take Avloclor).
Tell your doctor or pharmacist if you are taking any of the following medicines. This is because Avloclor may affect the amount of these medicines in your blood.
Also tell your doctor or pharmacist if you are taking any of the following medicines:
Antacids may reduce the amount of Avloclor absorbed from your gut. This may mean that the full dose of Avloclor is not absorbed into your body and it will not work properly. Therefore, you should take your antacid dose at least four hours before or after taking your Avloclor dose.
Some medicines (for example, ciprofloxacin, cimetidine, omeprazole, pyrimethamine) may increase the amount of Avloclor in your body and this can cause side effects. It is important that you do not take any additional medicines (either prescribed or non-prescribed) before speaking to your doctor.
If you need a vaccination against rabies, make sure you have it before you start your anti-malarial medicine. If you have your rabies injection at the same time as taking your anti-malarial medicine, your rabies vaccine might not work so well.
If you know you are to have a live oral typhoid vaccination, you must tell your doctor beforehand as your treatment with Paludrine might need to be adjusted.
Pregnancy
If you are pregnant or may become pregnant, talk to a doctor or pharmacist:
Paludrine can affect the levels of folic acid in the body, therefore pregnant women taking Paludrine should be given supplements that contain folic acid.
Breast-feeding
Driving and using machines
Sometimes Avloclor tablets cause blurred eyesight or make it difficult to focus your eyes. If this happens to you, do not drive or use any tools or machines.
Possible side effects
Like all medicines, your Anti-malarial Travel Pack can cause side effects, although not everybody gets them.
Allergic reactions
If you have an allergic reaction, stop using your Anti-malarial Travel Pack and get medical help or contact your doctor straight away. The signs may include:
Other possible side effects
Heart
Lungs
If you develop serious breathlessness or worsening of breathlessness seek prompt medical advice.
Mouth
Nervous system
Behaviour
Skin
Hair
Eyes
If you are using your Anti-malarial Travel Pack for a long time, your doctor may suggest that you have eye tests.
Ears
Blood
If you are using your Anti-malarial Travel Pack for a long time, your doctor may suggest that you have blood tests.
Liver
If you are using your Anti-malarial Travel Pack for a long time, your doctor may suggest that you have blood tests to check how well your liver is working.
Stomach and gut
Other
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the internet at www.mhra.gov.uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.
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