Macrobid Nitrofurantoin SR 100MG CAPSULES 14 CAPSULES

Macrobid Nitrofurantoin SR 100MG CAPSULES 14 CAPSULES

Nitrofurantoin (the active substance in MacroBID) is an antibiotic.

It is used to prevent and treat infections of the bladder, kidney and other parts of the urinary tract.



Macrobid Nitrofurantoin SR 100MG CAPSULES 14 CAPSULES

Nitrofurantoin (the active substance in MacroBID) is an antibiotic. It is used to prevent and treat infections of the bladder, kidney and other parts of the urinary tract.

Macrobid Nitrofurantoin SR 100MG CAPSULES 14 CAPSULES

 WHAT MacroBID Nitrofurantoin  IS AND WHAT IT IS USED FOR?

Nitrofurantoin (the active substance in MacroBID) is an antibiotic.

It is used to prevent and treat infections of the bladder, kidney and other parts of the urinary tract.

Adults and children over 12 years old:

The normal dosage depends on the type of infection you have and instructions should be written on the label provided by the pharmacist.

Consult your pharmacist or doctor if these instructions are not clear.

The usual doses are:

  • For treatment of bladder infections: One capsule twice a day for seven days
  • For prevention of bladder infections during surgery: One capsule twice a day on the day of the operation and three days thereafter.

Use in children

MacroBID is not recommended for children under 12 years of age.

MacroBID should be taken with food or milk.

Medical Checks:

Your doctor will watch carefully for any effects on the liver, lungs, blood or nervous system. MacroBID may interfere with the results of some tests for glucose in the urine.




Like all medicines, this medicine can cause side effects, although not everybody gets them. Most of them are mild and disappear when you stop taking MacroBID. If you experience any of the side effects detailed below or any other side effects, stop taking MacroBID and consult your doctor.

All medicines can cause allergic reactions although serious allergic reactions are rare. If you notice any sudden wheeziness, difficulty in breathing, swelling of the eyelids, face or lips, rash or itching (especially affecting your whole body) STOP TAKING your medicine and go to a doctor immediately.

Please note that while taking MacroBID your urine may become coloured dark yellow or brown. This is quite normal and not a reason to stop taking the medicine.

If you notice any of the following side effects consult your doctor immediately:

  • Your lungs may react to MacroBID. This may develop quickly, within a week of starting treatment or very slowly, especially in elderly patients. This may produce fever, chills, cough and shortness of breath
  • MacroBID may cause the liver to become inflamed, producing jaundice (yellowing of the skin or whites of the eyes)
  • Severe reduction in blood cells which can cause weakness, bruising or make infections more likely
  • Blue or purple coloration of the skin due to low oxygen levels. A condition known as cyanosis.
  • Symptoms of fever, flu, abdominal pain, diarrhea, blood in your stool and weakness. These could be signs of a condition known as cutaneous vasculitis.
  • Symptoms of fatigue, abdominal pain, joint pain and swelling. These could be signs of a condition known as hepatitis.

Other side effects are:

Rare (may affect up to 1 in 1,000 people)

  • Loss of consciousness (collapse).

Not known (frequency cannot be estimated from the available data)

  • Feeling sick (nausea) and headache
  • Loose stools
  • Loss of appetite, stomach ache, and being sick (vomiting)
  • Diarrhea
  • Dizziness, drowsiness
  • Blood cells have been affected in some patients. This may result in bruising, delayed clotting of the blood, sore throat, fever, anaemia, and a susceptibility to colds or persistent cold
  • The nerves outside the spinal cord may be affected causing changes to the sense of feeling and the use of muscles. In addition headache, extreme changes of mood or mental state, confusion, weakness, blurred vision may occur. These effects may be severe and in some instances permanent
  • A variety of skin rashes or reactions have occurred in some patients. These may appear as flaking skin, a red rash or fever accompanied by rapid heart rate and severe rash with blistering. Other reactions may include inflammation of salivary glands (causing facial pains), inflammation of the pancreas gland (causing severe abdominal pain) and joint pains.
  • Short-term hair loss
  • Raised pressure in the skull (causing severe headaches)
  • Urinary infection by germs which are not sensitive to MacroBID
  • Inflammation of small blood vessel walls, causing skin lesions
  • Liver inflammation due to turn of immune system against liver cells
  • Inflammation of kidney tissue surrounding tubules, causing renal impairment.


  • if you are allergic to Nitrofurantoin, other medicines containing nitrofurantoin or any of the other ingredients of this medicine (listed in section 6)
  • if you have a disease of the kidneys which is severely affecting the way they work (ask your doctor if you are not sure)
  • if you are in the final stages of pregnancy (labour or delivery) as there is a risk that it might affect the baby
  • if you have porphyria (blood disorder)
  • if in patients with G6PD (glucose-6-phosphate dehydrogenase) deficiency
  • if in infants under three months of age
  • if you are breast feeding a baby with suspected or known deficiency in an enzyme called G6PD (glucose-6-phosphate dehydrogenase).

Tell your doctor if you are not sure about any of the above.

Warnings and precautions

Talk to your doctor, pharmacist or nurse before taking MacroBID:

  • if you have diabetes
  • if you are suffering from any illness causing severe weakness
  • if you have anaemia (a decrease in red blood cells causing pale skin, weakness and breathlessness); a lack of vitamin B or abnormal levels of salts in your blood (your doctor will be able to advise you)
  • if you have a history of allergic reactions
  • if you have any problems with your kidneys.

The above conditions may increase the chance of developing a side effect which causes damage to the nerves, altered sense of feeling, like pins and needles.

  • if you lack an enzyme (body chemical) called glucose-6-phosphate dehydrogenase, which causes your red blood cells to be more easily damaged (this is more common in black people and people of Mediterranean, Middle Eastern or Asian origin. Your doctor will know)
  • if you have any disease of the lungs, liver or nervous system. If you need to take MacroBID for a number of months, your doctor may want to regularly check how your lungs and liver are working
  • if you have false positive results on testing your urine for glucose
  • if you have urine coloured yellow or brown
  • If you experience fatigue, yellowing of the skin or eyes, itching, skin rashes, joint pain, abdominal discomfort, nausea, vomiting, loss of appetite, dark urine, and pale or gray-colored stools. It may be symptoms of liver disorder.

Other medicines and MacroBID:

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription. If they are taken with MacroBID their effect or the effect of MacroBID may be changed.

In particular, tell your doctor or pharmacist if you are taking any of the following medicines:

  • Antacids for indigestion (e.g. magnesium trisilicate)
  • Medicines for gout (e.g. probenecid or sulfinpyrazone)
  • Medicines for raised pressure in the eye (glaucoma), such as carbonic anhydrase inhibitors (e.g. acetazolamide)
  • Medicines which make the urine less acidic (e.g. potassium citrate mixture)
  • Medicines for infections, known as quinolones
  • Typhoid vaccine, which is given for the prevention of typhoid.

If you are in doubt about any of these medicines ask your doctor or pharmacist.

MacroBID with food and drink:

MacroBID capsules should be taken at meal times with food or milk. This will help to avoid stomach upset and also to help the absorption.

Pregnancy and breast-feeding:

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

As far as it is known MacroBID may be used in pregnancy.

However it should not be used during labour or delivery because there is a possibility that use at this stage may affect the baby.

If you want to breast feed, please consult with your doctor first.

Driving and using machines:

MacroBID may cause dizziness and drowsiness. You should not drive or operate machinery if you are affected this way until such symptoms go away.

MacroBID contains lactose:

This medicine contains lactose and sucrose (sugars). If you have been told by your doctor that you are intolerant to some sugars and have to avoid them, contact your doctor before taking this medicine.

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