HOW YOU WILL BE GIVEN GONAPEPTYL DEPOT
The powder and solvent are normally mixed and injected by a healthcare professional.
Depending on the condition you are being treated for, the appropriate dose will be administered by intramuscular injection (into a muscle) or subcutaneous injection (just under the skin).
In Men:
– One injection of GONAPEPTYL Depot is normally given every 4 weeks as a long-term therapy
In Women:
– One injection of GONAPEPTYL Depot is normally given every 4 weeks for up to six months. – Treatment must be started during the first 5 days of the menstrual cycle.
In Children:
– At the beginning of treatment one injection should be injected on days 0, 14 and 28.
– The dose is adjusted according to body weight. Children weighing less than 20kg are given 1.875mg (1/2 dose); children weighing 20 – 30kg are given 2.5mg (2/3 dose); children weighing more than 30kg are given 3.75mg.
– Thereafter, injections are given every 3 – 4 weeks, according to effect.
The treatment duration is monitored by your doctor
BEFORE YOU ARE GIVEN GONAPEPTYL DEPOT
You must not be given GONAPEPTYL Depot – If you are allergic to triptorelin or any of the other ingredients of GONAPEPTYL Depot. – If you are allergic to gonadotropin-releasing hormone (GnRH) or any other GnRH analogues. In Women: – If you are pregnant or are breast feeding. Take special care with GONAPEPTYL Depot Men and women: – There have been reports of depression in patients taking Gonapeptyl which may be severe. If you are taking Gonapeptyl and develop depressed mood, inform your doctor. – As GONAPEPTYL Depot can lead to mood changes. – As treatment with GONAPEPTYL Depot in rare cases can lead to brain hemorrhage (pituitary apoplexia). Contact your doctor immediately if you experience sudden headache, vomiting or visual disturbances. – As treatment with GONAPEPTYL Depot can led to thinning of bones which increases risk of bone injury. – If you are at additional risk of thinning of the bones (osteoporosis) you should tell you doctor before taking GONAPEPTYL Depot. Risk factors include: o If any of your close family have thinning of the bones. o If you drink excessive amounts of alcohol, have a poor diet and/or smoke heavily. o If you are also being treated with certain medicines which may affect the strength of bone. In Men: Tell your doctor – If you have pains in your bones, or difficulty passing urine. – If you have a secondary spinal or urinary tract tumour. – If you are castrated – if you are diagnosed with diabetes – If you have a high risk of heart disease, such as diagnosed high blood pressure or heart rhythm problems (arrhythmia). – If you have any heart or blood vessel conditions, including heart rhythm problems (arrhythmia), or are being treated with medicines for these conditions. The risk of heart rhythm problems may be increased when using GONAPEPTYL. During treatment: During the beginning of therapy with GONAPEPTYL Depot you may experience a worsening in your disease symptoms. Contact your doctor if any of your symptoms of the disease get worse
In Women: Tell your doctor – II fyou are experiencing bleeding mid-cycle during treatment (except for the first month). During treatment: Non-hormonal methods of contraception, such as a condom or a diaphragm, should be used during the first month after the first injection. It should also be used from 4 weeks after the last injection until the return of your periods (menstruation). Your periods will stop during treatment. Once treatment has finished, your periods (menstruation) will resume 7-12 weeks after the final injection. If your periods (menstruation) persists during treatment, please inform your doctor. In Children: – Treatment should only be started in girls under 9 years of age and boys under 10 years of age. Tell your doctor – If your child suffers from a bad or recurrent headache, problems with eyesight and ringing or buzzing in the ears, contact a doctor immediately (see section 4). During treatment: In the first month of treatment girls can experience mild to moderate episodes of vaginal bleeding. After finalising the therapy, development of puberty characteristics will occur. In most girls menses will start on average one year after ending the therapy, which in most cases is regular. For any possible side effects please see section 4. Using other medicines Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. GONAPEPTYL Depot might interfere with some medicines used to treat heart rhythm problems (e.g. quinidine, procainamide, amiodarone and sotalol) or might increase the risk of heart rhythm problems when used with some other drugs (e.g. methadone (used for pain relief and part of drug addiction detoxification), moxifloxacin (an antibiotic), antipsychotics used for serious mental illnesses). Pregnancy and lactation GONAPEPTYL Depot must not be used during pregnancy and lactation (see also the section ‘You must not be given GONAPEPTYL Depot’). If you are possibly pregnant, pregnancy should be ruled out by your doctor before you should use GONAPEPTYL Depot. Women of childbearing potential should use effective non-hormonal contraception, such as a condom or a diaphragm, during treatment with GONAPEPTYL Depot until menstruation resumes. Driving and using machines There are no known effects on the ability to drive or use machinery. However it cannot be ruled out that the ability to drive or use machinery can be affected during treatment due to some of the side effects (dizziness, sleep disturbances/insomnia and disturbed eye vision. Take extra caution if you experience these side effects.
POSSIBLE SIDE EFFECTS
Like all medicines, GONAPEPTYL Depot can cause side effects, although not everybody gets them. General (all patients): If you experience swelling of the face, lips, mouth or throat which may cause difficulty in swallowing or breathing tell your doctor immediately or go to your nearest casualty department. Cases of pre-existing pituitary tumour enlargement were reported during treatment with LH-RH agonists, however it has not yet been observed with triptorelin therapy.
In Men:
The symptoms you are being treated for (e.g. urinary obstruction, skeletal pain, compression of the spinal cord, muscular discomfort and oedema of the legs, weakness and tingling in the feet and hands) may worsen initially, due to the increased levels of testosterone at the start of treatment. Very common, more than 1 patient out of every 10 patients treated: most of the side effects of GONAPEPTYL Depot in men result from lowered testosterone levels. Impotence, decreased libido, hot flushes, bone pain and difficulty and pain in passing urine can be seen. Common, between 1 and 10 patients out of every 100 patients treated: allergic reaction, depressed mood, mood changes, depression, sleep disorder, nausea, muscle and joint pain, tiredness, injection site reaction, injection site pain, irritability, excessive sweating, headache and breast enlargement in males. Uncommon, between 1 and 10 patients out of every 1000 patients treated: elevated values of some liver enzymes, anaphylactic reaction, testicular wasting, high blood pressure, decreased appetite, dry mouth, upper abdominal pain, asthma aggravated, weight changes, embolism, hair loss and reduced hair growth.
Not known, frequency cannot be estimated from the available data: • common cold • diabetes mellitus • gout • abdominal bloating • vertigo • constipation • diarrhoea • shortness of breath • injection site redness • influenza like symptoms • sleepiness • blurred vision • sensation of tingling, pricking or numbness • memory impairment • taste disturbances • visual impairment • abnormal sensation in eye • tinnitus • increased appetite • general discomfort • anxiety • loss of libido • dizziness • insomnia • chest pain • confusional state • chills • decreased activity • breast pain • fever • testicular pain • weakness • joint swelling • ejaculation failure • musculoskeletal stiffness • osteoarthritis • back pain • shortness of breath when lying flat • purple discoloration of skin • joint stiffness • musculoskeletal pain • pain in extremities • flatulence • muscular weakness • blisters • hives • angioedema (swelling that occurs under the skin) • muscle spasms • vomiting • itching • abdominal pain • acne • low blood pressure • rash • euphoric mood • nose bleeds • body temperature increased • difficulty in standing • oedema • elevated values of some liver and kidney enzymes • increased blood pressure • changes in ECG (QT prolongation) • injection site inflammation • pain
In Women:
Very common, more than 1 patient out of every 10 patients treated: decreased libido, mood changes, sleep disorder, hot flushes, abdominal pain, bone pain, excessive sweating, vaginal bleeding/spotting, vulvovaginal dryness, painful sexual intercourse, painful menstruation, enlargement of ovaries, pelvic pain, weakness and headache. Common, between 1 and 10 patients out of every 100 patients treated: allergic reaction, depressed mood, depression, nausea, muscle and joint pain, tiredness, injection site reaction, injection site pain, irritability. Uncommon, between 1 and 10 patients out of every 1000 patients treated: anaphylactic reaction, visual impairment, sensation of tingling, pricking or numbness, back pain, increased blood cholesterol, elevated values of some liver enzymes. Not known, frequency cannot be estimated from the available data: • abdominal discomfort • fever • heavy, prolonged and/or irregular periods • dizziness • angioedema (swelling that occurs under the skin) • blood pressure increased • loss of menstrual period • breast pain • loss of bone mineral leading to increased bone weakness • injection site redness • itching • rash • anxiety • general discomfort • diarrhoea • vomiting • vertigo • muscle weakness • blurred vision • hives • confusional state • shortness of breath • weight changes • muscle spasms • injection site inflammation
In Children:
Common, between 1 and 10 patients out of every 100 patients treated: mood changes, depression. Uncommon, between 1 and 10 patients out of every 1000 patients treated: in girls vaginal bleeding or discharge may occur. Nausea, vomiting and anaphylactic reaction have been seen. Not known, frequency cannot be estimated from the available data: • pain • headache • blurred vision • abdominal discomfort • genital haemorrhage • blood pressure increase • weight gain • Injection site pain, inflammation and redness • general discomfort • muscle pain • emotional lability • allergic reactions • nervousness • abdominal pain • visual impairment • nose bleeds • hot flushes • rash • hives • hair loss • angioedema (swelling that occurs under the skin) • redness • loosening or separation of growth zone of tubular bones • idiopathic intracranial hypertension (increased intracranial pressure around the brain characterised by headache, double vision and other visual symptoms, and ringing or buzzing in the ears) Reporting of side effects If you get any side effects, talk to your doctor. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme, website: www.mhra.gov.uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.
What GONAPEPTYL Depot contains
The powder: – The powder in each pre-filled syringe contains 4.12 mg of triptorelin acetate equivalent to 3.75 mg of the active substance, triptorelin. –
The other ingredients are Poly-(d,l lactide coglycolide), Propylene glycol dicaprylocaprate
The solvent contains: – Dextran 70, polysorbate 80, sodium chloride, sodium hydrogen phosphate dihydrate, sodium hydroxide and water for injection.
HOW TO STORE GONAPEPTYL DEPOT
Keep out of the reach and sight of children. Do not use GONAPEPTYL Depot after the expiry date which is stated on the packaging. The expiry date refers to the last day of that month. Store in a refrigerator (2ºC-8ºC)’. Keep the container in the outer carton. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
Click here for the Patient Information leaflet
Please read before using the product
There are no questions yet, be the first to ask something for this product.
Lubion 25mg Injection – Progesterone 25mg Injection, 7 Ampoules Introducing Lubion Injection – Your Pathway to Successful Pregnancy Are you undergoing treatment in an Assisted Reproductive Technology (ART) program and in need of extra progesterone? Look no further than Lubion Injection, a cutting-edge solution designed to support your journey towards becoming pregnant and maintaining a […]
Learn More£98.50
Original price was: £290.10.£236.60Current price is: £236.60.
Original price was: £290.10.£236.60Current price is: £236.60.
Hormone Replacement Therapy (HRT)
Active ingredient: Estradiol Valerate 2mg
Learn More£15.99
£220.00
Original price was: £480.20.£377.00Current price is: £377.00.
Original price was: £480.20.£377.00Current price is: £377.00.
Sucralfate Suspension 1g/5ml, 200ml Effective Ulcer Treatment and Stomach Protection Sucralfate Suspension 1g/5ml is a highly effective treatment for stomach ulcers and inflammation, offering targeted relief and protection from further irritation caused by stomach acid. This suspension works by forming a protective barrier over ulcers, allowing them to heal and preventing further damage. Ideal for […]
Learn More£291.20
Fostimon 75IU Injections – Urofollitropin, 10 Vials Promoting Ovulation for Fertility Treatment Fostimon 75IU Injections are specially formulated to aid ovulation in women who are experiencing difficulties conceiving due to a lack of ovulation or have not responded to other fertility treatments, such as clomifene citrate. Fostimon contains Urofollitropin, a highly purified form of human […]
Learn More£448.50
Tolak Cream – Fluorouracil 40mg/g cream, 20g Effective Treatment for Actinic Keratosis (Sun-Damaged Skin) Tackle sun-damaged skin effectively with Tolak Cream (Fluorouracil 40mg/g), specially formulated to treat actinic keratosis (AK) on the face, ears, and scalp in adults. Tolak works by destroying pre-cancerous and cancerous cells on the skin, promoting healing while minimizing damage to […]
Learn More£39.00
Chlorambucil 2mg Tablets, 25 Tablets Target Cancer Effectively with Chlorambucil 2mg Tablets – For Human and Veterinary Use Chlorambucil 2mg Tablets are a potent chemotherapy medication used to treat various types of cancers, including chronic lymphocytic leukemia, Hodgkin’s lymphoma, and non-Hodgkin’s lymphoma. This medication works by inhibiting the growth and spread of cancer cells, making […]
Learn More£28.50
Nutrizym 22 Capsules – Amylase Lipase Digestive Enzymes, 100 Capsules Experience the transformative health benefits with Nutrizym 22 Capsules, your go-to solution for optimal digestive health. Each capsule is expertly formulated with a powerful blend of amylase and lipase enzymes, designed to effectively break down fats, carbohydrates, and proteins in your diet. Perfect for individuals […]
Learn More£49.95
Hydramed Night Sensitive Eye Ointment, 5g
Learn More£16.45
Original price was: £153.60.£131.50Current price is: £131.50.
Mycophenolate 180mg Tablets – Mycophenolic acid 180mg, 120 Tablets Introducing Mycophenolate 180mg Tablets – Mycophenolic Acid 180mg: your ally in maintaining transplant success and managing autoimmune diseases. Mycophenolate 180mg Tablets are a vital immunosuppressant designed to safeguard transplanted organs from rejection by the body. Falling under the category of “immunosuppressants,” this medication works by efficiently […]
Learn MoreOriginal price was: £153.60.£131.50Current price is: £131.50.
Ursodeoxycholic Acid Tablets 300mg – Destolit Generic, 60 Tablets Introducing Ursodeoxycholic Acid Tablets 300mg – Your Solution for Gallstone Management and Liver Health Ursodeoxycholic Acid 300mg Tablets is a cutting-edge pharmaceutical formulation designed to positively influence bile composition, making it a versatile solution for various health concerns. Ursodeoxycholic Acid, the active ingredient in these tablets, […]
Learn More£100.42
Click one of our contacts below to chat on WhatsApp