Side Effects

Like all medicines, Duotrav eye drops can cause side effects although not everybody gets them.
You can usually carry on using the drops, unless the effects are serious. If you are worried, talk to a
doctor or pharmacist. Do not stop using DuoTrav without speaking to your doctor.
Very common side effects (may affect more than 1 in 10 people)
Effects in the eye
Eye redness.
Common side effects (may affect up to 1 in 10 people)
Effects in the eye
Eye surface inflammation with surface damage, eye pain, blurred vision, abnormal vision, dry eye,
itchy eye, eye discomfort, signs and symptoms of eye irritation (e.g. burning, stinging).
Uncommon side effects (may affect up to 1 in 100 people)
Effects in the eye
Inflammation of the eye surface, inflammation of the eyelid, swollen conjunctiva, increased growth of
eyelashes, iris inflammation, eye inflammation, sensitivity to light, reduced vision, tired eyes, eye
allergy, eye swelling, increased tear production, eyelid redness, eyelid colour change, skin darkening
(around the eye).
General side effects
Allergic reaction to active substance, dizziness, headache, increased or decreased blood pressure,
shortness of breath, excessive hair growth, drip at back of throat, skin inflammation and itching,
decreased heart rate.
Rare side effects (may affect up to 1 in 1,000 people)
Effects in the eye
Thinning of the eye surface, inflammation of the eyelid glands, broken blood vessel in the eye, eyelid
crusting, abnormally positioned eyelashes, abnormal growth of lashes.
General side effects
Nervousness, irregular heart rate, loss of hair, voice disorders, difficulty breathing, cough, throat
irritation, hives, abnormal liver blood tests, skin discolouration, thirst, tiredness, discomfort inside of
nose, coloured urine, pain in hands and feet.
Not known (frequency cannot be estimated from the available data)
Effects in the eye
Droopy eyelid (making the eye stay half closed), sunken eyes (eyes appear more inset), changes in the
colour of the iris (coloured part of the eye).
General side effects
Rash, heart failure, chest pain, stroke, fainting, depression, asthma, increased heart rate, numbness or
tingling sensation, palpitations, swelling in the lower limbs, bad taste.
Additionally:
DuoTrav is a combination of two active substances, travoprost and timolol. Like other medicines
administered to the eyes, travoprost and timolol (a beta blocker) are absorbed into the blood. This may
cause side effects similar to those seen when beta-blocking medicines that are administered by mouth
or by injection. The incidence of side effects after administration to the eyes is lower than after
5
administration by mouth or by injection.
The side effects listed below include reactions seen with the class of beta blockers used for treating
eye conditions or reactions seen with travoprost alone:
Effects in the eye
Inflammation of the eyelid, inflammation in the cornea, detachment of the layer below the retina that
contains blood vessels following filtration surgery which may cause visual disturbances, decreased
corneal sensitivity, corneal erosion (damage to the front layer of the eyeball), double vision, eye
discharge, swelling around the eye, eyelid itching, outward turning of eyelid with redness, irritation
and excessive tears, blurred vision (sign of clouding of the eye lens), swelling of a section of the eye
(uvea), eczema of the eyelids, halo vision, decreased eye sensation, pigmentation inside the eye,
dilatated pupils, change in eyelash colour, change in the texture of the eyelashes, abnormal field of
vision.
General side effects
Ear and labyrinth disorders: dizziness with spinning sensation, ringing in the ears.
Heart and circulation: slow heart rate, palpitations, oedema (fluid build-up), changes in heartbeat
rhythm or speed, congestive heart failure (heart disease with shortness of breath and swelling of the
feet and legs due to fluid build-up), a type of heart rhythm disorder, heart attack, low blood pressure,
Raynaud’s phenomenon, cold hands and feet, reduced blood supply to the brain.
Respiratory: constriction of the airways in the lungs (predominantly in patients with pre-existing
disease), runny or stuffy nose, sneezing (due to allergy), difficulty breathing, nose bleed, nasal
dryness.
Nervous system and general disorders: difficulty sleeping (insomnia), nightmares, memory loss,
hallucinations, loss of strength and energy, anxiety (excessive emotional distress).
Gastrointestinal: taste disturbances, nausea, indigestion, diarrhoea, dry mouth, abdominal pain,
vomiting and constipation.
Allergy: increased allergic symptoms, generalised allergic reactions including swelling beneath the
skin that can occur in areas such as the face and limbs and can obstruct the airway. which may cause
difficulty swallowing or breathing, localised and generalised rash, itchiness, severe sudden
life-threatening allergic reaction.
Skin: skin rash with white silvery coloured appearance (psoriasiform rash) or worsening of psoriasis,
peeling skin, abnormal hair texture, inflammation of the skin with itchy rash and redness, hair colour
change, loss of eyelashes, itching, abnormal hair growth, skin redness.
Muscular: increases in signs and symptoms of myasthenia gravis (muscle disorder), unusual
sensations like pins and needles, muscle weakness/tiredness, muscle pain not caused by exercise, joint
pain.
Renal and urinary disorders: difficulty and pain when passing urine, involuntary leakage of urine,
Reproduction: sexual dysfunction, decreased libido.
Metabolism: low blood sugar levels, increase in prostate cancer marker.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects
not listed in this leaflet. You can also report side effects directly via the national reporting system (see details below). By reporting side effects you can help provide more information on the safety of this medicine.