Toctino 10 mg Capsules – Alitretinoin 10mg, 30 Capsules

The product is only available on prescription of a registered Doctor / Vet and other registered prescribers. You can order this product now, but it will not be shipped until we have received your valid prescription. Once you have ordered we will email you different ways to get your prescription to us.

£719.50

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Toctino 10 mg Capsules – Alitretinoin 10mg, 30 Capsules

If you suffer from severe chronic hand eczema, Toctino 10mg Capsules could be the treatment you’ve been looking for. Toctino contains the active ingredient alitretinoin, which belongs to a group of medicines known as retinoids. These are related to Vitamin A and have been shown to be effective in treating chronic hand eczema. Toctino capsules come in two strengths, 10mg or 30mg, and treatment must be supervised by a specialist skin doctor. So if you’re looking for a effective way to treat your chronic hand eczema, ask your dermatologist about Toctino today.

Toctino can be prescribed for use in cats and dogs when prescribed by vet

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What is the price of  Toctino 10 mg Capsules?

The price of  Toctino 10 mg Capsules is £641.83

Where can you buy Toctino 10 mg Capsules?

You can buy Toctino 10 mg Capsules at Dock Pharmacy Essex UK, UK Online Pharmacy.

Can you buy Toctino 10 mg Capsules Over the counter?

Toctino 10 mg Capsules is not available to buy over the counter. You need a prescription to buy Toctino 10 mg Capsules

 

Brand

Toctino

How To Use

When to take the capsules

The capsule should be taken with a main meal, preferably at the same time each day.

The capsules should be swallowed whole and not chewed.

How much to take

The dose is either 10 or 30 mg once daily. If your body can’t tolerate the recommended 30 mg dose, you may be prescribed the lower 10 mg dose. Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.

How long should you take the capsules

A course of treatment usually lasts for 12 to 24 weeks depending how your disease gets better. If your first treatment was successful, your doctor may prescribe another course of treatment if symptoms return.

 

 

Delivery Options

Delivery options

All deliveries are subject to the availability of the product and product sale conditions been met.

Order & Collect
Free next-day collection from In-Store

UK Delivery

Standard Delivery within the UK £3.50 Delivery time 3-4 days
First Class Delivery within the UK £5.90 Delivery time 1-2 days
Priority Delivery within the UK £7.10. Next day delivery by 1pm. Order must be placed by 1pm. Priority delivery is only available Monday to Thursday.

Europe Delivery

Standard Delivery within EEC from £12.50 Delivery time up to 5 days depending on the local delivery service within your country.
Expedited Delivery within EEC £39.50 Delivery time 2 days. Delivery by DHL, UPS or TNT.

Rest of the World

Standard Delivery Rest of the World from £16.10 Delivery Time 10 – 15 Days
Expedited Delivery Rest of the World £55.09 Delivery 5 days. Delivery service by DHL, TNT or UPS

For more information see our Shipping Policy or view our Return policy.

Product Details

What you need to know before you take Toctino

Do not take Toctino • If you are pregnant or breast-feeding • If there is any chance you could become pregnant, you must follow the precautions under “Pregnancy and prevention programme”, see section on “Warnings and precautions”. • If you have liver disease. • If you have severe kidney disease. • If you have high blood fats (such as high cholesterol or raised triglycerides). • If you have untreated thyroid disease. • If you have very high levels of vitamin A in your body (hypervitaminosis A). • If you are allergic to alitretinoin, to other retinoids (such as isotretinoin), to peanut or soya or any of the other ingredients of this medicine (listed in section 6). • If you are taking tetracycline (a type of antibiotic). Ø If any of these apply to you, go back to your doctor. You must not take Toctino. Warnings and precautions Talk to your doctor before taking Toctino: • If you have ever had any kind of mental health problems. This includes depression, aggressive tendencies or mood changes. It also includes thoughts about hurting yourself or ending your life. This is because your mood may be affected while taking Toctino. • If you have kidney disease. Toctino is not recommended for people with moderate kidney disease. If you have kidney disease – check with your doctor that Toctino is suitable for you. • If you have high blood fats, you may need blood tests more often. Toctino commonly increases blood fats, such as cholesterol or triglycerides. If your blood fats stay high, your doctor may lower your dose, or take you off Toctino. • If you have high blood sugar (diabetes), your blood sugar levels may need to be checked more often and your doctor may start you on a lower dose of Toctino. • If you have been suffering from thyroid disease. Toctino may lower your thyroid hormone levels. If your thyroid hormone level is low, your doctor may prescribe supplements. You need to take care during treatment: • If you experience any problems with your sight, tell your doctor immediately. Toctino may need to be stopped and your sight monitored. • If you get a persistent headache, nausea or vomiting (feeling or being sick) and blurred vision, these may be signs of a condition called benign intracranial hypertension. Stop the capsules immediately and contact your doctor as soon as possible. • If you have bloody diarrhoea stop the capsules immediately and contact your doctor as soon as possible. • Minimise your exposure to sunlight and avoid sun lamps. Your skin may become more sensitive to sunlight. Before you go out in the sun, use a sun protection product with a high protection factor (SPF 15 or higher). If you get dry skin and lips during treatment, use a moisturising ointment or cream and a lip balm. • Cut down on intensive physical exercise: alitretinoin can cause muscle and joint pain. • If you develop dry eyes, lubricating eye ointment or tear replacement drops can help. If you wear contact lenses, you may need to wear glasses during alitretinoin treatment. Dry eyes and sight problems normally return to normal once treatment is stopped. • Toctino may increase liver enzyme levels. Your doctor will do blood tests during treatment to check these levels. If they stay high, your doctor may lower your dose or take you off of Toctino. Mental health problems • You may notice some changes in your mood and behaviour and so it is very important that you tell your friends and family that you are taking this medicine. They may notice these changes and help you quickly identify any problems that you need to talk to your doctor about. • If you develop any mental health problems including depression, aggressive tendencies, mood changes, thoughts about hurting yourself or ending your life, you must stop taking Toctino immediately and contact your doctor as soon as possible. Children and adolescents Toctino is not recommended for people aged under 18 years old. It is not known how well it works in this age group. Other medicines and Toctino Do not take other retinoid medicines (e.g. isotretinoin), vitamin A supplements or tetracyclines (a type of antibiotic) while taking Toctino. This increases the risk of side effects. Tell your doctor or pharmacist if: Ø you are taking amiodarone (a medicine that helps to regulate heart rate). Amiodarone is not recommended to be taken together with Toctino. Ø you are taking ketoconazole, fluconazole, miconazole (medicines used to treat infections). Your doctor may decide to reduce your dose of Toctino. Ø you are taking simvastatin (a medicine used to lower cholesterol). Toctino may decrease the amount of this medicine in your body. Ø you are taking gemfibrozil (another medicine used to lower cholesterol) or oxandrolone (an anabolic steroid). Your doctor may decide to reduce your dose of Toctino. Ø you are taking paclitaxel (used to treat cancer), rosiglitazone or repaglinide (used to treat diabetes). Toctino may increase the amount of these medicines in your body. Tell your doctor or a pharmacist if you are taking, or have recently taken or might take any other medicines. This includes medicines obtained without a prescription, and herbal medicines. Pregnancy Prevention Programme Women who are pregnant must not take Toctino This medicine can seriously harm an unborn baby (the medicine is said to be “teratogenic”). It can cause serious abnormalities of the unborn baby’s brain, face, ear, eye, heart and certain glands (thymus gland and parathyroid gland). It also makes a miscarriage more likely. This may happen even if Toctino is taken only for a short time during pregnancy. • You must not take Toctino if you are pregnant or if you think you might be pregnant. • You must not take Toctino if you are breast-feeding. The medicine is likely to pass into your milk and may harm your baby. • You must not take Toctino if you could get pregnant during treatment • You must not get pregnant for one month after stopping this treatment because some medicine may still be left in your body. Women who could get pregnant are prescribed Toctino under strict rules. This is because of the risk of serious harm to the unborn baby These are the rules: • Your doctor must have explained the risk of harm to the unborn baby – you must understand why you must not get pregnant and what you need to do to prevent getting pregnant. • You must have talked about contraception (birth control) with your doctor. The doctor will give you information how not to get pregnant. The doctor may send you to a specialist for contraception advice. • Before you start treatment, your doctor will ask you to take a pregnancy test. The test must show that you are not pregnant when starting treatment with Toctino. Women must use effective contraception before, during and after taking Toctino • You must agree to use at least one very reliable method of contraception (for example an intra uterine device or contraceptive implant) or two effective methods that work in different ways (for example a hormonal contraceptive pill and a condom). Discuss with your doctor which method would be suitable for you. • You must use contraception for a month before taking Toctino, during treatment and for a month afterwards. • You must use contraception even if you do not have periods or you are not sexually active (unless your doctor decides this is not necessary). Women must agree to pregnancy testing before, during and after taking Toctino • You must agree to regular follow-up visits, ideally every month. • You must agree to have regular pregnancy tests, ideally every month during treatment and, because some medicine may still be left in your body, 1 month after stopping Toctino, (unless your doctor decides this is not necessary in your case). • You must agree to extra pregnancy tests if your doctor asks you. • You must not get pregnant during treatment or for a month afterwards because some medicine may still be left in your body. • Your doctor will discuss all these points with you, using a checklist and will ask you (or a parent/guardian) to sign it. This form confirms that you have been told about the risks, and that you will follow the rules above. Ø If you get pregnant while taking Toctino, stop taking the medicine straight away, and contact your doctor. Your doctor may send you to a specialist for advice. Also, if you become pregnant within one month after you stop taking Toctino, you should contact your doctor. Your doctor may send you to a specialist for advice. Your doctor will provide you written information on pregnancy. If you have not seen this information, ask your doctor. Advice for men The levels of oral retinoid in the semen of men taking Toctino are too low to harm their partners’ unborn baby. However, you must never share your medication with anyone. Additional precautions You should never give this medicinal product to another person. Please take any unused capsules to your pharmacist at the end of the treatment. You should not donate blood during treatment with this medicine and for 1 month after stopping Toctino because an unborn baby could be harmed if a pregnant patient receives your blood. Pregnancy and breast-feeding Do not take Toctino if you are breast-feeding • The medicine is likely to pass into your milk and may harm your baby. Do not take Toctino if you are pregnant Toctino is likely to cause severe birth defects (in medical language it is teratogenic). It also increases the risk of miscarriage. • You must not take Toctino when you are pregnant. • You must not get pregnant during treatment with Toctino, or during the month after treatment. For more information on pregnancy and contraception, see section 2 “Pregnancy and prevention programme”. Driving and using machines You may not see as well at night during your treatment. If this happens to you, you should not drive or operate machinery. Toctino contains soya oil and sorbitol If you are allergic to peanut or soya, do not use this medicinal product. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking Toctino. Each 10 mg capsule of Toctino contains 20.08 mg sorbitol. Each 30 mg capsule of Toctino contains 25.66 mg sorbitol.

Side Effects

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them

Very common effects • Headache • Raised blood fats: higher levels of fats (triglycerides) and cholesterol in the blood. Common effects • Blood cell disorders: increase in the number of blood platelets (cells that help blood to clot), decrease in the number of red and white blood cells seen in blood tests. • Thyroid problems: decreased levels of thyroid hormones. • Eye problems: inflammation of the eye (conjunctivitis) and eyelid area; eyes feel dry and irritated. Ø Ask a pharmacist for suitable eye drops. If you wear contact lenses and get dry eyes, you may need to wear glasses instead. • Ear problems: persistent noise in the ears (tinnitus) • Dizziness • Blood and circulation: flushing, high blood pressure (hypertension) • Gut and stomach problems: feeling sick (nausea), being sick (vomiting), dry mouth • Muscle and joint pain: muscle pain, joint pain, lack of energy (fatigue). High levels of muscle breakdown products in your blood if you exercise vigorously. • Skin and hair problems: dryness of the skin, especially of the face, dry and inflamed lips, redness of the skin, itchy skin rash, inflamed skin, hair loss. • Liver problems: raised liver enzymes seen in blood tests. Uncommon effects • Sight problems including blurred vision, distorted vision, cloudy surface on the eye (corneal opacity, cataracts). Ø If your sight is affected, stop taking Toctino immediately and contact your doctor. • Skin problems: itchy skin, skin peeling, rash, dry skin eczema. • Ear, nose and throat problems: nose bleeding. • Gut and stomach problems: indigestion (dyspepsia) • Bone disorders: extra growth of bone, including the spine disorder ankylosing spondylitis. Rare effects • Lasting headache, along with feeling sick (nausea), being sick (vomiting) and changes in your eyesight including blurred vision. These may be signs of benign intracranial hypertension. Ø If you experience these symptoms, stop taking Toctino immediately and contact your doctor. • Blood and circulation: inflammation of blood vessels. • Skin, hair and nail problems: Nail disorders, increased sensitivity of the skin to sunlight, hair texture changes. Mental health problems Rare effects (may affect up to 1 in 1000 people) • Depression or related disorders. Signs of this include sad or altered mood, anxiety, feelings of emotional discomfort • Existing depression getting worse • Becoming violent or aggressive Very rare effects (may affect up to 1 in 10,000 people) • Some people have had thoughts or feelings about harming themselves or ending their own lives (suicidal thoughts), have tried to end their own lives (attempted suicide) or have ended their lives (suicide). These people may not appear to be depressed. • Unusual behaviour. • Signs of psychosis: a loss of contact with reality, such as hearing voices or seeing things that are not there. Ø Contact your doctor straight away if you get signs of any of these mental health problems. Your doctor may tell you to stop taking Toctino. That may not be enough to stop the effects: you may need more help, and your doctor can arrange this. Other side effects Other side effects have occurred in a very small number of people but their exact frequency is unknown: Severe allergic reactions. Signs include: • raised and itchy rash (hives) • swelling, sometimes of the face or mouth (angioedema), causing difficulty in breathing • collapse. Ø Contact a doctor immediately if you get these symptoms. Stop taking Toctino. Gut and stomach disorders. Severe stomach (abdominal) pain, with or without bloody diarrhoea, feeling sick (nausea) and being sick (vomiting). Ø Stop taking Toctino immediately and contact your doctor. These can be signs of serious gut conditions. Problems seeing at night: Sight problems normally return to normal once treatment is stopped. Blood and circulation: swelling of the hands, lower legs and feet (peripheral oedema). Side effects of other medicines in the same family as Toctino These effects haven’t been seen in Toctino so far, but they can’t be ruled out. They are very rare and may affect less than 1 user in 10,000. Diabetes: Excessive thirst: frequent need to urinate; blood tests show an increase in your blood sugar. These can all be signs of diabetes. Bone disorders: Arthritis; bone disorders (delayed growth, changes to bone density); growing bones may stop growing. Eye and visual disorders: Colour blindness and colour vision gets worse; intolerance to contact lenses. Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.

Ingredients

Ingredients

The active substance is alitretinoin.
Each capsule, soft contains 10 mg or 30 mg of alitretinoin.
The other ingredients are: soya bean oil (refined), partially hydrogenated soya bean oil, medium chain
triglycerides, yellow beeswax, all-rac-α-tocopherol, gelatin, glycerol, sorbitol liquid (noncrystallising), water purified, iron oxide, red (E172), iron oxide, black (E172) (10 mg) or iron oxide,
yellow (E172) (30 mg).

How to Store

How to Store

Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date, which is stated on the carton and blister after EXP. The expiry date refers to the last day of that month. Do not store above 30°C. Keep the blister in the outer carton in order to protect from light. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

 

Patient Information leaflet

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Please read before using the product

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