Rapamune Tablets – Sirolimus, 30 Tablets

5.00 out of 5 based on 1 customer rating

Rapamune Tablets is available in 3  strengths

1mg tablets, 2mg tablets & 0.5mg tablets


Rapamune Tablets is available in 3  strengths:

  • Rapamune 0.5mg Tablets – Sirolimus 0.5mg
  • Rapamune 1mg Tablets – Sirolimus 1mg
  • Rapamune 2mg Tablets – Sirolimus 2mg
The product is only available on prescription of a registered Doctor / Vet and other registered prescribers. You can order this product now, but it will not be shipped until we have received your valid prescription. Once you have ordered we will email you different ways to get your prescription to us.

£103.50£259.47

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Rapamune Tablets is available in 3  strengths:

  • Rapamune 0.5mg Tablets - Sirolimus 0.5mg
  • Rapamune 1mg Tablets - Sirolimus 1mg
  • Rapamune 2mg Tablets - Sirolimus 2mg

Rapamune Tablets – Sirolimus, 30 Tablets

Rapamune Tablets are an immunosuppressant medication used after kidney transplantation to help control your body’s immune system. This prescription drug contains the active substance sirolimus, which mediates its effects by preventing the immune system from attacking the transplanted organ and is essential in reducing the risk of organ rejection. In order to improve post-transplant outcomes, Rapamune Tablets are gradually increased up to a maintenance level following transplantation, allowing your immune system to accommodate your new organ in a safe, regulated way. As a medical-grade immunosuppressant therapy, Rapamune helps reduce episodes of acute rejection so you can move forward with life after a successful transplant.

Rapamune is used in adults to prevent your body from rejecting transplanted kidneys and is normally used with other immunosuppressant medicines called corticosteroids and initially (the first 2 to 3 months) with ciclosporin.

Rapamune is also used for the treatment of patients with sporadic lymphangioleiomyomatosis (S-LAM) with moderate lung disease or declining lung function. S-LAM is a rare progressive lung disease that affects predominantly women of childbearing age. The most common symptom of S-LAM is shortness of breath.

Rapamune Tablets is available in 3  strengths:

  • Rapamune 0.5mg Tablets – Sirolimus 0.5mg
  • Rapamune 1mg Tablets – Sirolimus 1mg
  • Rapamune 2mg Tablets – Sirolimus 2mg

Rapamune Tablets Reviews

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What is the price of  Rapamune Tablets?

The price of  Rapamune Tablets starts from £103.50

Where can you buy Rapamune Tablets?

You can buy Rapamune Tablets at Dock Pharmacy Essex UK, UK Online Pharmacy.

Can you buy Rapamune Tablets Over the counter?

Rapamune Tablets is not available to buy over the counter. You need a prescription to buy Rapamune Tablets

Brand

Strengths

1mg Tablets, 2mg Tablets, 0.5mg Tablets

Brand

Rapamune

How To Use

How to take Rapamune

Always take this medicine exactly as your doctor has told you.

Check with your doctor or pharmacist if you are not sure.

Your doctor will decide exactly what dose of Rapamune you must take and how often to take it. Follow your doctor’s instructions exactly, and never change the dose yourself.

Rapamune is for oral use only.

Do not crush, chew, or split the tablets.

Inform your doctor if you have difficulty taking the tablet.

Multiples of 0.5 mg tablets should not be used as a substitute for 1 mg and 2 mg tablets, as the different strengths are not directly interchangeable.

Rapamune should be taken consistently, either with or without food.

Delivery Options

Delivery options

All deliveries are subject to the availability of the product and product sale conditions been met.

Order & Collect
Free next-day collection from In-Store

UK Delivery

Standard Delivery within the UK £3.50 Delivery time 3-4 days
First Class Delivery within the UK £5.90 Delivery time 1-2 days
Priority Delivery within the UK £7.10. Next day delivery by 1pm. Order must be placed by 1pm. Priority delivery is only available Monday to Thursday.

Europe Delivery

Standard Delivery within EEC from £12.50 Delivery time up to 5 days depending on the local delivery service within your country.
Expedited Delivery within EEC £39.50 Delivery time 2 days. Delivery by DHL, UPS or TNT.

Rest of the World

Standard Delivery Rest of the World from £16.10 Delivery Time 10 – 15 Days
Expedited Delivery Rest of the World £55.09 Delivery 5 days. Delivery service by DHL, TNT or UPS

For more information see our Shipping Policy or view our Return policy.

Product Details

What you need to know before you take Rapamune

Do not take Rapamune: – if you are allergic to sirolimus or any of the other ingredients of this medicine (listed in section 6). Warnings and precautions Talk to your doctor or pharmacist before taking Rapamune − If you have any liver problems or have had a disease which may have affected your liver, please tell your doctor as this may affect the dose of Rapamune that you receive and may result in your having additional blood tests. Page 2 of 7 − Rapamune, like other immunosuppressive medicines, may decrease your body’s ability to fight infection, and may increase the risk of developing cancer of the lymphoid tissues and skin. − If you have a body mass index (BMI) greater than 30 kg/m2 , you may be at increased risk of abnormal wound healing. − If you are considered to be at high risk for kidney rejection, such as if you had a previous transplant that was lost to rejection. Your doctor will perform tests to monitor the levels of Rapamune in your blood. Your doctor will also perform tests to monitor your kidney function, your blood fat (cholesterol and/or triglycerides) levels and possibly your liver function, during treatment with Rapamune. Exposure to sunlight and UV light should be limited by covering your skin with clothing and using a sunscreen with a high protection factor because of the increased risk for skin cancer. Children and adolescents There is limited experience on the use of Rapamune in children and adolescents less than 18 years of age. The use of Rapamune is not recommended in this population. Other medicines and Rapamune Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Some medicines can interfere with the action of Rapamune and, therefore, dose adjustment of Rapamune may be required. In particular, you should inform your doctor or pharmacist if you are taking any of the following: − any other immunosuppressant medicines. − antibiotics or antifungal medicines used to treat infection e.g. clarithromycin, erythromycin, telithromycin, troleandomycin, rifabutin, clotrimazole, fluconazole, itraconazole. It is not recommended that Rapamune be taken with rifampicin, ketoconazole or voriconazole. − any high blood pressure medicines or medicines for heart problems including nicardipine, verapamil and diltiazem. − anti-epileptic medicines including carbamazepine, phenobarbital, phenytoin. − medicines used to treat ulcers or other gastrointestinal disorders such as cisapride, cimetidine, metoclopramide. − bromocriptine (used in the treatment of Parkinson’s disease and various hormonal disorders), danazol (used in the treatment of gynaecological disorders), or protease inhibitors (e.g., for HIV and hepatitis C such as ritonavir, indinavir, boceprevir, and telaprevir). − St. John’s Wort (Hypericum perforatum). − letermovir (an antiviral medicine to prevent getting ill from cytomegalovirus). The use of live vaccines should be avoided with the use of Rapamune. Before vaccinations, please inform your doctor or pharmacist that you are receiving Rapamune. The use of Rapamune may lead to increased levels of cholesterol and triglycerides (blood fats) in your blood that may require treatment. Medicines known as “statins” and “fibrates” used to treat elevated cholesterol and triglycerides have been associated with an increased risk of muscle breakdown (rhabdomyolysis). Please inform your doctor if you are taking medicines to lower your blood fats. The combined use of Rapamune with angiotensin-converting enzyme (ACE) inhibitors (a type of medicine used to lower blood pressure) may result in allergic reactions. Please inform your doctor if you are taking any of these medicines. Rapamune with food and drink Page 3 of 7 Rapamune should be taken consistently, either with or without food. If you prefer to take Rapamune with food, then you should always take it with food. If you prefer to take Rapamune without food, then you should always take it without food. Food can affect the amount of medicine that gets into your bloodstream, and taking your medicine in a consistent way means that the blood levels of Rapamune remain more stable. Rapamune should not be taken with grapefruit juice. Pregnancy, breast-feeding and fertility Rapamune should not be used during pregnancy unless clearly necessary. You must use an effective method of contraception during treatment with Rapamune and for 12 weeks after treatment has stopped. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. It is not known whether Rapamune passes into breast milk. Patients taking Rapamune should discontinue breast-feeding. Decreased sperm count has been associated with the use of Rapamune and usually returns to normal once treatment is stopped. Driving and using machines Although Rapamune treatment is not expected to affect your ability to drive, if you have any concerns please consult your doctor. Rapamune contains lactose and sucrose Rapamune contains 86.4 mg of lactose and up to 215.8 mg of sucrose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.

Side Effects

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Allergic reactions You should see your doctor immediately if you experience symptoms, such as swollen face, tongue and/or back of the mouth (pharynx) and/or difficulties in breathing (angioedema), or a skin condition whereby the skin can peel off (exfoliative dermatitis). These may be symptoms of a serious allergic reaction. Kidney damage with low blood cell counts (thrombocytopaenic purpura/haemolytic uraemic syndrome) When taken with medicines called calcineurin inhibitors (ciclosporin or tacrolimus), Rapamune may increase the risk of kidney damage with low blood platelets and low red blood cell counts, with or without rash (thrombocytopaenic purpura/haemolytic uraemic syndrome). If you experience symptoms such as bruising or rash, changes in your urine, or changes in behaviour or any others that are serious, unusual or prolonged, contact your doctor. Infections Rapamune reduces your body’s own defence mechanisms. Consequently your body will not be as good as normal at fighting infections. So if you are taking Rapamune, you may therefore catch more infections than usual, such as infections of the skin, mouth, stomach and intestines, lungs and urinary tract (see list below). You should contact your doctor if you experience symptoms that are serious, unusual, or prolonged. Page 5 of 7 Side effect frequencies Very common: may affect more than 1 in 10 people − Fluid collection around the kidney − Swelling of the body including hands and feet − Pain − Fever − Headache − Increased blood pressure − Stomach pain, diarrhoea, constipation, nausea − Low red blood cells, low blood platelets − Increased fat in the blood (cholesterol and/or triglycerides), increased blood sugar, low blood potassium, low blood phosphorus, increased lactate dehydrogenase in the blood, increased creatinine in the blood − Joint pain − Acne − Urinary tract infection − Pneumonia and other bacterial, viral, and fungal infections − A reduced number of infection-fighting cells in the blood (white blood cells) − Diabetes − Abnormal tests of liver function, elevated AST and/or ALT liver enzymes − Rash − Elevated protein in the urine − Menstrual disorders (including absent, infrequent or heavy periods) − Slow healing (this may include separation of the layers of a surgical wound or stitch line) − Rapid heart rate − There is a general tendency for fluid to collect in various tissues. Common: may affect up to 1 in 10 people − Infections (including life-threatening infections) − Blood clots in the legs − Blood clots in the lung − Mouth sores − Fluid collection in the abdomen − Kidney damage with low blood platelets and low red blood cell counts, with or without rash (haemolytic uraemic syndrome) − Low levels of a type of white blood cells called neutrophils − Deterioration of bone − Inflammation that may lead to lung damage, fluid around the lung − Nose bleeds − Skin cancer − Kidney infection − Ovarian cysts − Fluid collection in the sac around the heart, that in some cases may decrease the heart’s ability to pump blood − Inflammation of the pancreas − Allergic reactions − Shingles − Cytomegalovirus infection Uncommon: may affect up to 1 in 100 people Page 6 of 7 − Cancer of the lymph tissue (lymphoma/post-transplant lympho-proliferative disorder), combined lowering of red blood cells, white blood cells and blood platelets − Bleeding from the lung − Protein in the urine, occasionally severe and associated with side effects, such as swelling − Scarring in the kidney that may reduce kidney function − Too much fluid collecting in the tissues due to irregular lymph function − Low blood platelets, with or without rash (thrombocytopaenic purpura) − Serious allergic reactions that can cause peeling of the skin − Tuberculosis − Epstein-Barr virus infection − Infectious diarrhoea with Clostridium difficile − Serious liver damage Rare: may affect up to 1 in 1,000 people − Protein build-up in the air sacs of the lungs that may interfere with breathing − Serious allergic reactions that can affect blood vessels (see above paragraph on allergic reactions) Not known: frequency cannot be estimated from the available data − Posterior reversible encephalopathy syndrome (PRES), a serious nervous system syndrome that has the following symptoms: headache, nausea, vomiting, confusion, seizures, and visual loss. Should any of these occur together, please contact your physician. S-LAM patients experienced similar side effects to those of kidney transplant patients, with the addition of weight loss, which may affect up to 1 in 10 people. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine

Ingredients

What Rapamune contains

The active substance is sirolimus.

Each Rapamune 0.5 mg coated tablet contains 0.5 mg of sirolimus.

Each Rapamune 1 mg coated tablet contains 1 mg of sirolimus.

Each Rapamune 2 mg coated tablet contains 2 mg of sirolimu

How to Store

How to store Rapamune

Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date, which is stated on the blister and carton after “EXP”. The expiry date refers to the last day of that month. Do not store above 25˚C. Keep the blister in the outer carton in order to protect from light. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

Patient Information leaflet

Click here for the Patient Information leaflet

Please read before using the product

1 review for Rapamune Tablets – Sirolimus, 30 Tablets

    • 5 out of 5
    Rapamune Tablets – Sirolimus, 30 Tablets

    Helen Watson (verified owner)

    (0) (0)
    Rapamune Tablets – Sirolimus, 30 Tablets

    Jumoke Odebiyi

    Dear Helen, we appreciate your 5-star rating.

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