Description

Esomeprazole Injection 40mg – Generic Nexium 40mg Injection, 1 Vial

Esomeprazole Injection 40mg is an intravenous proton pump inhibitor (PPI) used when oral treatment is not appropriate. It reduces stomach acid production and is prescribed for severe GERD, erosive oesophagitis, and bleeding gastric or duodenal ulcers. Supplied as a single 40mg vial (generic Nexium IV). Prescription required. It is specifically indicated for the prevention of rebleeding following endoscopy for acute GI bleeds. As the S-isomer of omeprazole, it provides rapid and sustained pH control.

When rapid acid suppression is vital or oral administration is impossible, Esomeprazole Injection 40mg provides the clinical standard in gastric protection. This single-dose vial contains 40mg of esomeprazole sodium (as a lyophilized powder) for reconstitution, offering high-velocity pH stabilization for acute gastro-oesophageal reflux, NSAID-induced ulcers, and the prevention of post-endoscopy rebleeding.

Prescription Required: This is a POM (Prescription Only Medicine). Every order includes a clinical review by our GPhC-registered pharmacists at Dock Pharmacy to ensure therapeutic compliance.

Esomeprazole Injection 40mg contains esomeprazole sodium, an intravenous proton pump inhibitor (PPI) designed for short-term acid suppression when oral therapy cannot be administered. It is commonly used in hospital or specialist settings for severe acid-related gastrointestinal conditions.

Mechanism of Action

Esomeprazole works by irreversibly inhibiting the gastric H⁺/K⁺-ATPase enzyme (proton pump) in the stomach lining.

By blocking this enzyme:

• Gastric acid secretion is significantly reduced

• Oesophageal inflammation can heal

• Active ulcer bleeding risk is reduced

• Gastric pH increases to stabilise clot formation in upper GI bleeding

Intravenous administration allows rapid onset of acid suppression, particularly important in acute or hospital-managed cases.

What Is Esomeprazole Injection 40mg Used For?

Esomeprazole IV 40mg is prescribed for:

• Severe gastro-oesophageal reflux disease (GERD)

• Erosive oesophagitis

• Upper gastrointestinal bleeding

• Peptic ulcer haemorrhage

• Patients unable to take oral medication

• Short-term hospital acid suppression therapy

Veterinary Use: Horses, Dogs & Cats

In 2026, Esomeprazole IV has become a high-demand “extra-label” tool in veterinary care:

• Horses: Used for Equine Glandular Gastric Disease (EGGD). Research suggests IV esomeprazole (0.5mg/kg) can resolve lesions refractory to oral omeprazole paste.

• Dogs & Cats: Indicated for acute GI bleeding, severe erosive oesophagitis, or when vomiting prevents oral PPI intake.

• Safety Warning: Intravenous administration site reactions can occur. Always ensure the injection site is clean and monitored

When Is IV Esomeprazole Preferred Over Capsules?

Intravenous esomeprazole is used when:

• The patient cannot swallow

• There is active upper GI bleeding

• Immediate acid suppression is clinically required

• Post-operative acid control is necessary

Once stabilised, patients are typically switched to oral therapy such as esomeprazole capsules.

How It Is Administered

• Administered by healthcare professionals only

• Given as IV injection or infusion

• Typical dose: 40mg once daily (or as directed by specialist)

• Dosing may vary in acute bleeding protocols

This medicine is not self-administered.

Benefits of Esomeprazole 40mg Injection

• Rapid acid suppression

• Supports stabilisation in upper GI bleeding

• Promotes ulcer healing

• Effective alternative when oral therapy is unsuitable

• Hospital-grade short-term treatment

Possible Side Effects

Common side effects may include:

• Headache

• Nausea

• Injection site reaction

• Abdominal discomfort

Less common but important risks:

• Electrolyte imbalance (e.g., low magnesium)

• Vitamin B12 deficiency (long-term use)

• Increased infection risk with prolonged therapy

Medical monitoring is recommended during treatment.

Cautions & Contraindications

Use with caution in:

• Severe liver impairment

• Long-term use beyond recommended duration

• Patients on clopidogrel

Do not use if allergic to esomeprazole or other PPIs.

Always use under medical supervision.

Veterinary / Off-Label Use

Esomeprazole may be prescribed off-label by veterinary surgeons for:

• Gastric ulceration in horses

• Acid-related gastritis in dogs and cats

Veterinary dosing protocols differ significantly from human dosing. Only use under veterinary supervision.

Why Buy from Dock Pharmacy?

Dock Pharmacy is a GPhC-registered UK pharmacy, ensuring:

• Prescription validation before supply

• Clinical review by qualified pharmacists

• MHRA-compliant sourcing

• Secure pharmaceutical distribution

• Reliable UK dispatch

When purchasing Esomeprazole 40mg injection UK, you receive regulated, pharmacist-supervised supply from an established and trusted provider.

Prescription required – pharmacist review included.

For oral alternatives, see our range of esomeprazole 20mg capsules and other proton pump inhibitor treatments available via Dock Pharmacy.

FAQs

What is esomeprazole injection 40mg used for?

It is used for severe acid reflux, upper gastrointestinal bleeding and ulcer management when oral treatment is not suitable.

When is IV esomeprazole preferred over capsules?

IV therapy is used in hospital settings when rapid acid suppression is required or the patient cannot take oral medication.

How does esomeprazole injection work?

It blocks the proton pump in the stomach lining, significantly reducing acid production and promoting healing.

What are the side effects of esomeprazole IV?

Common effects include headache and nausea. Serious risks are rare but may include electrolyte imbalance with prolonged use.

Is esomeprazole injection the same as Nexium IV?

Yes, this is a generic equivalent containing the same active ingredient (esomeprazole) at the same strength.

Can esomeprazole injection be used in animals?

It may be prescribed off-label by veterinary professionals for ulcer management in horses, dogs and cats.

How do I reconstitute Esomeprazole 40mg for my horse?

For a 40mg dose, add 5ml of 0.9% Sodium Chloride to the vial. The solution should be clear and colourless. Administration must be performed by a veterinary professional or under strict veterinary guidance.

Can Esomeprazole Injection be used for dogs with gastritis?

Yes, it is used off-label in veterinary clinics for dogs with severe vomiting or GI ulcers. The IV route ensures 100% bioavailability, bypasses the “vomit reflex,” and stabilizes the stomach lining faster than oral meds.

How long is the reconstituted solution stable?

Chemically, it is stable for 12 hours at 30°C, but from a microbiological standpoint, it should be used immediately after preparation to prevent infection.

Esomeprazole 40mg injection (generic Nexium IV) is a hospital-grade intravenous acid suppression therapy. It is indicated for short-term management of severe gastro-oesophageal reflux disease (GERD), upper gastrointestinal bleeding and peptic ulcer haemorrhage when oral PPIs cannot be used. Supplied by Dock Pharmacy with prescription verification and pharmacist oversight.

Looking for Generic Nexium IV? Esomeprazole 40mg Injection is a critical tool for acute gastric acid suppression. It is increasingly utilized in equine veterinary medicine as a first-line treatment for Equine Glandular Gastric Disease (EGGD), often outperforming oral pastes. Dock Pharmacy ensures 2026 stock availability for hospitals, clinics, and veterinary surgeries, providing high-standard pharmaceutical care with expert oversight