Cyclogest 400mg Pessary, Pack 15

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Active Ingredient: Progesterone

Use in IVF

Use in Adult Women Only

Prescription Product


  • Active Ingredient: Progesterone
  • Use in IVF
  • Use in Adult Women Only
  • Prescription Product
The product is only available on prescription of a registered Doctor / Vet and other registered prescribers. You can order this product now, but it will not be shipped until we have received your valid prescription. Once you have ordered we will email you different ways to get your prescription to us.

£19.50

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  • Active Ingredient: Progesterone
  • Use in IVF
  • Use in Adult Women Only
  • Prescription Product

Cyclogest 400mg Pessary, Pack 15

What Cyclogest 400mg is and what it is used for

Cyclogest 400mg Pessary is a medication used to treat various conditions in women, such as insufficient progesterone levels and endometrial hyperplasia. It is a natural, female sex hormone, produced in the body and helps to maintain regular monthly periods.

Cyclogest is also known as Amelgen

Cyclogest works by adjusting the hormonal balance within the body for the treatment of:

  • pre-menstrual syndrome which often affects women during the 7 to 10 days before their monthly period. The symptoms of pre-menstrual syndrome include feelings of tension, irritability, depression, headache, breast tenderness, weight gain and bloatedness
  • post-natal depression which some women get after their baby has been born.
  • women who need extra progesterone while undergoing treatment in an Assisted Reproductive Technology (ART) programme.
  • Luteal phase support as part of an Assisted Reproductive Technology(ART) treatment for women and IVF Treatment

What is Infertility and IVF?

Infertility is when a couple cannot get pregnant (conceive) despite having regular unprotected sex.

Around 1 in 7 couples may have difficulty conceiving.

About 84% of couples will conceive naturally within a year if they have regular unprotected sex (every 2 or 3 days).

For couples who have been trying to conceive for more than 3 years without success, the likelihood of getting pregnant naturally within the next year is 1 in 4, or less.

Some people get pregnant quickly, but for others it can take longer. It’s a good idea to see a GP if you have not conceived after a year of trying.

Women aged 36 and over, and anyone who’s already aware they may have fertility problems, should see their GP sooner.

They can check for common causes of fertility problems and suggest treatments that could help.

Infertility is usually only diagnosed when a couple have not managed to conceive after a year of trying.

There are 2 types of infertility:

  • primary infertility – where someone who’s never conceived a child in the past has difficulty conceiving
  • secondary infertility – where someone has had 1 or more pregnancies in the past, but is having difficulty conceiving again

Read more about how infertility is diagnosed.

Fertility treatments include:

  • medical treatment for lack of regular ovulation
  • surgical procedures such as treatment for endometriosis, repair of the fallopian tubes, or removal of scarring (adhesions) within the womb or abdominal cavity
  • assisted conception such as intrauterine insemination (IUI) or IVF

The treatment offered will depend on what’s causing the fertility problems and what’s available from your local clinical commissioning group (CCG).

Private treatment is also available, but it can be expensive and there’s no guarantee it will be successful.

It’s important to choose a private clinic carefully. You can ask a GP for advice, and should make sure you choose a clinic that’s licensed by the Human Fertilisation and Embryology Authority (HFEA).

Some treatments for infertility, such as IVF, can cause complications.

For example:

  • multiple pregnancy – if more than 1 embryo is placed in the womb as part of IVF treatment there’s an increased chance of having twins; this may not seem like a bad thing, but it significantly increases the risk of complications for you and your babies
  • ectopic pregnancy – the risk of having an ectopic pregnancy is slightly increased if you have IVF

Read more about how infertility is treated.

There are many possible causes of infertility, and fertility problems can affect either partner. But in a quarter of cases it is not possible to identify the cause.

Common causes of infertility include:

  • lack of regular ovulation (the monthly release of an egg)
  • poor quality semen
  • blocked or damaged fallopian tubes
  • endometriosis – where tissue that behaves like the lining of the womb (the endometrium) is found outside the womb

RISK FACTORS

There are also several factors that can affect fertility.

These include:

  • age – fertility declines with age
  • weight – being overweight or obese (having a BMI of 30 or over) reduces fertility; in women, being overweight or severely underweight can affect ovulation
  • sexually transmitted infections (STIs) – several STIs, including chlamydia, can affect fertility
  • smoking – can affect fertility: smoking (including passive smoking) affects your chance of conceiving and can reduce semen quality; read more about quitting smoking
  • alcohol – the safest approach is not to drink alcohol at all to keep risks to your baby to a minimum. Drinking too much alcohol can also affect the quality of sperm (the chief medical officers for the UK recommend adults should drink no more than 14 units of alcohol a week, which should be spread evenly over 3 days or more)
  • environmental factors – exposure to certain pesticides, solvents and metals has been shown to affect fertility, particularly in men
  • stress – can affect your relationship with your partner and cause a loss of sex drive; in severe cases, stress may also affect ovulation and sperm production

There’s no evidence to suggest caffeinated drinks, such as tea, coffee and colas, are associated with fertility problems.

What is IVF

In vitro fertilisation (IVF) is one of several techniques available to help people with fertility problems have a baby.

During IVF, an egg is removed from the woman’s ovaries and fertilised with sperm in a laboratory.

The fertilised egg, called an embryo, is then returned to the woman’s womb to grow and develop.

It can be carried out using your eggs and your partner’s sperm, or eggs and sperm from donors.

SPEAKING TO YOUR GP ABOUT IVF

If you’re having trouble getting pregnant, you should start by speaking to your GP. They can advise on how to improve your chances of having a baby.

If these measures don’t work, your GP can refer you to a fertility specialist for a treatment such as IVF.

WHAT HAPPENS DURING IVF

IVF involves 6 main stages:

  1. suppressing your natural cycle – the menstrual cycle is suppressed with medication
  2. boosting your egg supply – medication is used to encourage the ovaries to produce more eggs than usual
  3. monitoring your progress and maturing your eggs – an ultrasound scan is carried out to check the development of the eggs, and medication is used to help them mature
  4. collecting the eggs – a needle is inserted into the ovaries, via the vagina, to remove the eggs
  5. fertilising the eggs – the eggs are mixed with the sperm for a few days to allow them to be fertilised
  6. transferring the embryo(s) – 1 or 2 fertilised eggs (embryos) are placed into the womb

Once the embryo(s) has been transferred into your womb, you’ll need to wait 2 weeks before taking a pregnancy test to see if the treatment has worked.

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Price of  Cyclogest 400mg Pessary in UK

Where to buy Cyclogest 400mg Pessary

Cyclogest 400mg Pessary is available to buy with a prescription at Dock Pharmacy Essex UK, UK Online Pharmacy.

Patient Information Leaflet

Brand

Cyclogest

How To use

How to use Cyclogest

Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.

For women undergoing Assisted Reproductive Technology (ART) programme:

The recommended dose is 400 mg twice a day by vaginal insertion. Start using Cyclogest 400 mg on the day of egg retrieval. The administration of Cyclogest should be continued for 38 days if pregnancy has been confirmed.

For the treatment of premenstrual syndrome and post-natal depression:

The recommended dose is 200 mg once a day or 400 mg twice a day by vaginal or rectal insertion.

The pessary may be inserted into either the vagina or rectum (back passage) depending upon the following certain other conditions.

You should insert Cyclogest into the:

  • vagina if you have:
    • colitis (inflammation of the colon causing frequent attacks of diarrhoea with mucous or blood)
    • problems controlling your bowel movements (faecal incontinence).
  • rectum (back passage) if you have:
    • a vaginal infection (discharge from your vagina)
    • or often have cystitis (a burning pain on passing water)
    • recently given birth
    • to use a barrier method of birth control such as a diaphragm, cap or condom.
      Such devices may not work properly in the presence of the hard fat from the pessary.

 

For premenstrual tension start using Cyclogest on day 12 or 14 of your menstrual cycle. This can be planned and marked onto your calendar; day 1 is the first day of your monthly period, counting forward to day 12 or 14 as advised by your doctor.

Do not swallow Cyclogest.

How to insert Cyclogest

Always wash your hands before and after inserting the pessary.

To insert into the:

  • Vagina – place the pessary between the lips of the vagina and push the pessary upwards and backwards. You may find it easier to do this if you are lying down or squatting.
  • Rectum (back passage) – gently push the pessary into the rectum for about one inch. Your muscles will hold the pessary in place when it is in far enough. Squeeze your buttocks together for a few seconds.

 

If you use more Cyclogest than you should

If you (or someone else) has accidentally swallowed any of the pessaries or you use too many, contact your nearest hospital casualty department or your doctor immediately for advice.

If you forget to use Cyclogest

If you forget to insert a pessary, do so as soon as you remember, unless it is nearly time for the next dose. Never use two doses together. Remember to use the remaining doses at the correct time.

If you stop using Cyclogest

Please consult your doctor or pharmacist for advice if you intend to stop or have stopped using Cyclogest. Abrupt discontinuation of progesterone dosing may cause increased anxiety, moodiness, and increased sensibility to seizures.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Caution / Warning

What you need to know before you use Cyclogest

Do not use Cyclogest if you:

  • are allergic to progesterone or any of the other ingredients of this medicine (listed in section 6),
  • have unusual vaginal bleeding that has not been evaluated by the doctor,
  • have known or suspected tumour that is hormone sensitive,
  • have porphyria disorders (a group of inherited or acquired disorders of certain enzymes),
  • have or have had blood clots in the legs, lungs, eyes or elsewhere in the body,
  • currently have or have had severe liver problems.
  • have a miscarriage and your physician suspects some tissue is still in the uterus or pregnancy outside of the womb.

 

Warnings and precautions

Talk to your doctor, pharmacist or nurse before using Cyclogest.

Take special care and tell your doctor straight away if you experience any of these symptoms during treatment or even few days after the last dosage:

  • pains in the calves or chest, a sudden shortness of breath or coughing blood indicating possible clots in the legs, heart, or lungs
  • severe headache or vomiting, dizziness, faintness, or changes in vision or speech, weakness or numbness of an arm or leg indicating possible clots in the brain or eye
  • worsening of depression

 

Check with your doctor or pharmacist before using Cyclogest if you have or ever have had:

  • liver problems such as jaundice (yellowing of the skin and whites of the eyes).
  • epilepsy
  • migraine
  • asthma
  • cardiac or renal dysfunction
  • diabetes

 

Children

There is no relevant use of Cyclogest in children.

Other medicines and Cyclogest

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This is especially important in case you are taking carbamazepine (e.g. to prevent fits, treat certain type of pain or mood disorders), rifampicin (to treat infections) or phenytoin (e.g. to prevent fits or treat certain type of pain) as they may decrease the effectiveness of progesterone.

Using other vaginal products at the same time as Cyclogest is used vaginally is not recommended as it is not known if it affects the treatment.

Pregnancy and breast-feeding

Cyclogest can be used during the first trimester of pregnancy for women who need extra progesterone while undergoing treatment in an Assisted Reproductive Technology (ART) programme.

The risks of congenital (conditions present at birth) anomalies, including genital abnormalities in male or female infants, from exposure to exogenous progesterone during pregnancy have not been fully established.

For other use, if you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.

This medicine should not be used during breast feeding.

 How to store Cyclogest

Keep this medicine out of the sight and reach of children.

Do not store above 30°C.

Do not use this medicine after the expiry date which is stated on the label/carton/bottle. The expiry date refers to the last day of that month.

Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

Side Effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Stop using Cyclogest and contact your doctor at once if you have an allergic reaction. Signs may include a skin rash, which may be itchy.

Common (may affect up to 1 in 10 people)

Drowsiness, stomach discomfort or pain, breast pain

Not known (frequency cannot be estimated from the available data)

Diarrhoea, soreness in your rectum (back passage), flatulence (wind), changes in your menstrual cycle (you may find that your monthly period will start earlier than usual or it may be delayed), leakage after the pessary has dissolved (this is quite normal when using medicines that are inserted into the vagina or rectum)

Adverse reactions in patients undergoing ART treatment is presented below:

Common side effects (may affect up to 1 in 10 people):

  • Abdominal distension (swelling in the abdomen), abdominal pain, constipation
  • Sleepiness
  • Tiredness
  • Hot flush
  • Breast pain

 

Uncommon side effects (may affect up to 1 in 100 people):

  • Headache, dizziness, mood changes
  • Change in taste, vomiting, flatulence (wind), diarrhoea, bloat (gastric dilatation), rectal tumour
  • Night sweats, skin rash or itching
  • Joint pain
  • Pelvic pain, ovarian enlargement, vaginal bleeding
  • Frequent urination, involuntary excretion of urine
  • Weight increase
  • Bleeding
  • Itching at the application site, feeling cold or body temperature change or general discomfort

 

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or via the Yellow Card app, which can be downloaded from the Apple App Store or Google Play Store. By reporting side effects you can help provide more information on the safety of this medicine.

Ingredients

What Cyclogest contains

  • The active substance (the ingredient that makes the medicine work) is progesterone. Each pessary contains 400 mg of the active Ingredient.
  • The other ingredients are hard fat.

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