J Collis Browne’s Mixture (Morphine Hydrochloride And Peppermint Oil) Has Cough Suppressant And Anti-Diarrhoeal Actions & Also Helps Reduce Painful Spasms And Pressure In The Bowel And Eases Bloating And Wind Associated With The Diarrhoea.
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J Collis Brownes Mixture (Morphine Hydrochloride And Peppermint Oil)
Morphine Is A Type Of Medicine Called An Opioid. In High Doses, It Is A Strong Painkiller, But It Also Has Cough Suppressant And Anti-Diarrhoeal Actions. This Medicine Contains A Low Dose Of Morphine That Is Not A Painkiller And Is Used Purely For Its Anti-Diarrhoeal Or Cough Suppressant Effect.
Morphine Relieves A Cough By Reducing The Nerve Signals Sent From A Part Of The Brain Called The Coughing Centre To The Muscles That Produce Coughing. This Blocks The Cough Reflex And Is Useful For Stopping A Tickly, Irritating Unproductive Cough.
Morphine Relieves Diarrhoea By Reducing The Speed At Which The Gut Contents Are Pushed Through The Intestines, Allowing More Time For Water And Electrolytes To Be Reabsorbed Back Into The Body. This Results In Firmer Stools That Are Passed Less Frequently.
Peppermint Oil Acts Directly On The Smooth Muscle In The Bowel Wall, Causing It To Relax. This Helps Reduce Painful Spasms And Pressure In The Bowel And Eases Bloating And Wind Associated With The Diarrhoea.
Click here For Patient Information Leaflet
For Diarrhoea: Adults, the elderly and children over 12 years: Take TWO or THREE 5ml spoonfuls (10-15ml) every 4 hours up to a maximum of three doses.
For dry and tickly coughs: Adults, the elderly and children over 12 years: Take ONE or TWO 5ml spoonfuls (5-10ml) every 4 hours.
Hypersensitivity to the active substances, to any of the excipients or to menthol.
Children under the age of 12 years.
Acute respiratory depression, chronic obstructive pulmonary disease, acute alcoholism, risk of paralytic ileus, acute ulcerative colitis, acute abdomen, delayed gastric emptying, raised intra-cranial pressure and head injury, and phaeochromocytoma. It should not be given during an attack of asthma or to patients with heart failure secondary to chronic lung disease.
Concurrent administration with monoamine oxidase inhibitors (MAOIs) or within 2 weeks of discontinuation of their use.
Acute hepatic disease
Obstructive bowel disorders
Administration of some opioid analgesics to patients taking a monoamine oxidase inhibitor (MAOI) has been associated with very severe and sometimes fatal reactions. If the use of J Collis Browne’s Mixture is considered essential, then great care should be taken in patients taking MAOIs or within 14 days of stopping MAOIs
Use with care in hypotension, shock, myasthenia gravis, prostatic hypertrophy, diseases of the biliary tract, and cardiac arrhythmias. Caution is advised in patients with asthma or other respiratory disorders, hepatic and renal disease, and a history of drug abuse.
Cough suppressants may cause sputum retention and this may be harmful in patients with chronic bronchitis, bronchiectasis and chronic obstructive pulmonary disease.
A reduced dose is recommended in elderly or debilitated patients, in hepatic and renal impairment (but avoid if severe), in hypothyroidism, and in adrenocortical insufficiency.
J Collis Browne’s Mixture is not intended as a substitute for rehydration therapy in the treatment of diarrhoea; patients should take plenty of fluids.
Risk from concomitant use of sedative medicines such as benzodiazepines or related drugs:
Concomitant use of morphine and sedative medicines such as benzodiazepines or related drugs may result in sedation, respiratory depression, coma and death. Because of these risks, concomitant prescribing with these sedative medicines should be reserved for patients for whom alternative treatment options are not possible. If a decision is made to prescribe this medicine concomitantly with sedative medicines, the lowest effective dose should be used, and the duration of treatment should be as short as possible.
The patients should be followed closely for signs and symptoms of respiratory depression and sedation. In this respect, it is strongly recommended to inform patients and their caregivers to be aware of these symptoms
Each 5ml contains:
Morphine hydrochloride equivalent to 1.0mg anhydrous Morphine
Peppermint Oil 1.5 microlitre
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Clinically proven to reduce diarrhoea and dehydrationLearn More
Pepto Bismol Upset Stomach Relief Liquid is used in those aged 16 years and over for fast relief of indigestion, heartburn, nausea, and upset stomach. It can also be used to help control diarrhoea.
• Easy to use
• As effective as physiotherapy
• Small and lightweight
• Suitable for both adults and children
• Easy to clean
They may be used to treat:
£5.60 – £68.60
£5.60 – £68.60