Bemfola Injection Prefilled Pen – Follitropin Alfa, Pack of 1


Bemfola Injection Prefilled Pen – Follitropin Alfa, Pack of 1 available in 5 different strenghts:

  • BEMFOLA PREFILLED PEN 150IU/0.25ML
  • BEMFOLA PREFILLED PEN 225IU/0.375ML
  • BEMFOLA PREFILLED PEN 300IU/0.5ML
  • BEMFOLA PREFILLED PEN 450IU/0.75ML
  • BEMFOLA PREFILLED PEN 75IU/0.125ML

 

 

 


£32.90£197.40

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Bemfola Injection Prefilled Pen - Follitropin Alfa, Pack of 1 available in 5 different strenghts:
  • BEMFOLA PREFILLED PEN 150IU/0.25ML
  • BEMFOLA PREFILLED PEN 225IU/0.375ML
  • BEMFOLA PREFILLED PEN 300IU/0.5ML
  • BEMFOLA PREFILLED PEN 450IU/0.75ML
  • BEMFOLA PREFILLED PEN 75IU/0.125ML
     

Bemfola Injection Prefilled Pen – Follitropin Alfa, Pack of 1

Looking to start or grow your family? Bemfola Injection Prefilled Pen can help! Bemfola Injection Prefilled Pen contains the active ingredient follitropin alfa, which is almost identical to a natural hormone produced by your body called “follicle-stimulating hormone” (FSH). FSH is a gonadotropin, a type of hormone that plays an important role in human fertility and reproduction. In women, FSH is needed for the growth and development of the sacs (follicles) in the ovaries that contain the egg cells. In men, FSH is needed for the production of sperm. So whether you’re trying to conceive on your own or with the help of assisted reproductive technologies (ART), Bemfola Prefilled Pen may be right for you. Speak to your doctor today to learn more about this exciting fertility treatment option!

What Bemfola is used for?

 In adult women, Bemfola is used:

  • to help release an egg from the ovary (ovulation) in women that cannot ovulate and that did not respond to treatment with a medicine called “clomiphene citrate”.
  • together with another medicine called “lutropin alfa” (“luteinising hormone” or LH) to help release an egg from the ovary (ovulation) in women that are not ovulating because their body is producing very little gonadotropins (FSH and LH).
  • to help develop several follicles (each containing an egg) in women undergoing assisted reproductive technology procedures (procedures that may help you to become pregnant) such as “in vitro fertilisation”, “gamete intra-fallopian transfer” or “zygote intra-fallopian transfer”.

 In adult men, Bemfola is used:

  • together with another medicine called “human chorionic gonadotropin” (hCG) to help produce sperm in men that are infertile due to a low level of certain hormones.

Bemfola Injection Prefilled Pen Reviews

After using Bemfola Injection Prefilled Pen, it’s helpful to let others know about your experience. Reviews of an item help other users know that medicines received have helped the condition it is claimed for, how well the treatment worked or any issues to be aware of. We invite our users to leave a review of both their treatment and of the service provided. Click on the reviews tab to see if there has been feedback on this item.

What is the price of  Bemfola Injection Prefilled Pen?

The price of  Bemfola Injection Prefilled Pen starts from £32.90

Where can you buy Bemfola Injection Prefilled Pen?

You can buy Bemfola Injection Prefilled Pen at Dock Pharmacy Essex UK, UK Online Pharmacy.

Can you buy Bemfola Injection Prefilled Pen Over the counter?

Bemfola Injection Prefilled Pen is not available to buy over the counter. You need a prescription to buy Bemfola Injection Prefilled Pen

 

Brand

Bemfola

Strength

75 IU/0.125 mL, 150 IU/0.25 mL, 225 IU/0.375 mL, 300 IU/0.50 mL, 450 IU/0.75 mL

How To Use

How to use Bemfola Injection Prefilled Pen

Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure

Using this medicine

  • Bemfola is intended to be given by injection just under the skin (subcutaneously). Use the prefilled pen only once then it should be disposed of in a safe manner. Do not administered the solution if it contains particles or is not clear.
  • The first injection of Bemfola should be given under supervision of your doctor.
  • Your doctor or nurse will show you how to use the Bemfola pre-filled pen to inject the medicine.
  • If you administer Bemfola to yourself, please carefully read and follow the “Instructions for Use”. These instructions can be found at the end of the package leaflet.

How much to use

Your doctor will decide how much medicine you will use and how often. The doses described below are stated in International Units (IU) and millilitres (mL).

Women:

 If you are not ovulating and have irregular or no periods

Bemfola is usually given every day.

  • If you have irregular periods, start using Bemfola within the first 7 days of your menstrual cycle. If you do not have periods you can start using the medicine on any convenient day.
  • The usual starting dose of Bemfola is 75 to 150 IU (0.12 to 0.25 mL) each day.
  • Your dose of Bemfola may be increased every 7 or every 14 days by 37.5 to 75 IU, until you get the desired response or your doctor tells you to stop, see below.
  • The maximum daily dose of Bemfola is usually not higher than 225 IU (0.375 mL).
  • When you get the desired response, you will be given a single injection of 250 micrograms of “recombinant hCG” (r-hCG, an hCG made in a laboratory by a special DNA technique), or 5,000 to 10,000 IU of hCG, 24 to 48 hours after your last Bemfola injection. The best time to have sex is on the day of the hCG injection and the day after.

If your doctor cannot see a desired response after 4 weeks, that treatment cycle with Bemfola should be stopped. For the following treatment cycle, your doctor will give you a higher starting dose of Bemfola than before.

If your body responds too strongly, your treatment will be stopped and you will not be given any hCG (see section 2, OHSS). For the following cycle, your doctor will give you a lower dose of Bemfola than before

If you are not ovulating, have no periods and have been diagnosed with very low levels of FSH and LH hormones

  • The usual starting dose of Bemfola is 75 to 150 IU (0.12 to 0.25 mL) together with 75 IU (0.12 mL) of lutropin alfa. • You will use these two medicines each day for up to five weeks.
  • Your dose of Bemfola may be increased every 7 or every 14 days by 37.5 to 75 IU, until you get the desired response.
  • When you get the desired response, you will be given a single injection of 250 micrograms of “recombinant hCG” (r-hCG, an hCG made in a laboratory by a special DNA technique), or 5,000 to 10,000 IU of hCG, 24 to 48 hours after your last injections of Bemfola and lutropin alfa. The best time to have sex is on the day of the hCG injection and the day after. Alternatively, intrauterine insemination may be performed by placing the sperm into the womb cavity

If you need to develop several eggs for collection prior to any assisted reproductive technology

The usual starting dose of Bemfola is 150 to 225 IU (0.25 to 0.37 mL) each day, from day 2 or 3 of your treatment cycle.

  • Bemfola dose may be increased, depending on your response. The maximum daily dose is 450 IU (0.75 mL).
  • Treatment is continued until your eggs have developed to a desired point. This usually takes about 10 days but can take any time between 5 and 20 days. Your doctor will use blood tests and/or an ultrasound machine to check when this is.
  • When your eggs are ready, you will be given a single injection of 250 micrograms “recombinant hCG” (r-hCG, an hCG made in a laboratory by a special recombinant DNA technique), or 5 5,000 IU to 10,000 IU of hCG, 24 to 48 hours after the last Bemfola injection. This gets your eggs ready for collection.

In other cases, your doctor may first stop you from ovulating by using a gonadotropin-releasing hormone (GnRH) agonist or antagonist. Then Bemfola is started approximately two weeks after start of agonist treatment. The Bemfola and GnRH agonist are then both given until your follicles develop as desired. For example, after two weeks of GnRH agonist treatment, 150 to 225 IU Bemfola is administered for 7 days. The dose is then adjusted according to your ovarian response. When GnRH antagonist is used, it is administered from the 5th or 6th day of Bemfola treatment and continued until ovulation induction.

Men

  • The usual dose of Bemfola is 150 IU (0.25 mL) together with hCG.
  • You will use these two medicines three times a week for at least 4 months.
  • If you have not responded to treatment after 4 months, your doctor may suggest that you continue using these two medicines for at least 18 months.

Delivery Options

Delivery options

All deliveries are subject to the availability of the product and product sale conditions been met.

Order & Collect
Free next-day collection from In-Store

UK Delivery

Standard Delivery within the UK £3.50 Delivery time 3-4 days
First Class Delivery within the UK £5.90 Delivery time 1-2 days
Priority Delivery within the UK £7.10. Next day delivery by 1pm. Order must be placed by 1pm. Priority delivery is only available Monday to Thursday.

Europe Delivery

Standard Delivery within EEC from £12.50 Delivery time up to 5 days depending on the local delivery service within your country.
Expedited Delivery within EEC £39.50 Delivery time 2 days. Delivery by DHL, UPS or TNT.

Rest of the World

Standard Delivery Rest of the World from £16.10 Delivery Time 10 – 15 Days
Expedited Delivery Rest of the World £55.09 Delivery 5 days. Delivery service by DHL, TNT or UPS

For more information see our Shipping Policy or view our Return policy.

Product Details

What you need to know before you use Bemfola Injection

You and your partner’s fertility should be evaluated before the treatment is started by a doctor experienced in treating fertility disorders. Do not use Bemfola • if you are allergic to follicle stimulating hormone or any of the other ingredients of this medicine (listed in section 6). • if you have a tumour in your hypothalamus or pituitary gland (both are parts of the brain). • If you are a woman: – with large ovaries or sacs of fluids within the ovaries (ovarian cysts) of unknown origin. – with unexplained vaginal bleeding. – with cancer in your ovaries, womb or breasts. – with a condition that usually makes normal pregnancy impossible, such as ovarian failure (early menopause), or malformed reproductive organs. • If you are a man: – with damaged testicles that cannot be healed. Do not use Bemfola if any of the above applies to you. If you are not sure, talk to your doctor or pharmacist before using this medicine. Warnings and precautions Porphyria Tell your doctor before you start treatment, if you or any member of your family have porphyria (an inability to break down porphyrins that may be passed on from parents to children). Tell your doctor straight away if: • your skin becomes fragile and easily blistered, especially skin that has been frequently in the sun, and/or • you have stomach, arm or leg pain. In case of the above events your doctor may recommend that you stop treatment. Ovarian Hyper-Stimulation Syndrome (OHSS) If you are a woman, this medicine increases your risk of developing OHSS. This is when your follicles develop too much and become large cysts. If you get lower abdominal pain, gain any weight rapidly, feel sick or are vomiting or if you have difficulty in breathing, talk to your doctor straight away who might ask you to stop using this medicine (see section 4). In case you are not ovulating, and if the recommended dose and schedule of administration are adhered to, the occurrence of OHSS is less likely. Bemfola treatment seldom causes severe OHSS unless the medicine that is used for final follicular maturation (containing human chorionic gonadotropin, hCG) is administered. If you are developing OHSS your doctor may not give you any hCG in this treatment cycle and you may be told not to have sex or to use a barrier contraceptive method for at least four days. Multiple pregnancy When using Bemfola, you have a higher risk of being pregnant with more than one child at the same time (“multiple pregnancy”, mostly twins), than if you conceive naturally. A multiple pregnancy may lead to medical complications for you and your babies. You can reduce the risk of multiple pregnancy by using the right dose of Bemfola at the right times. When undergoing assisted reproductive technology the risk of having a multiple pregnancy is related to your age, the quality and the number of fertilised eggs or embryos placed inside you. Miscarriage When undergoing assisted reproductive technology or stimulation of your ovaries to produce eggs, you are more likely to have a miscarriage than the average woman. Blood clotting problems (thromboembolic events) 3 If you had in the past or recently blood clots in the leg or in the lung, or a heart attack or stroke, or if those happened in your family, then you might have a higher risk that these problems occur or become worse with Bemfola treatment. Men with too much FSH in their blood If you are a man, having too much FSH in your blood can be a sign of damaged testicles. Bemfola usually does not work if you have this problem. If your doctor decides to try Bemfola treatment, to monitor the treatment, they may ask you to provide semen for analysis 4 to 6 months after starting treatment. Children and adolescents Bemfola is not indicated for use in children and adolescents under 18 years of age. Other medicines and Bemfola Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. • If you use Bemfola with other medicines which help ovulation (such as hCG or clomiphene citrate), this may increase the response of your follicles. • If you use Bemfola at the same time as a “gonadotropin-releasing hormone” (GnRH) agonist or antagonist (these medicines reduce your sex hormone levels and stop you ovulating) you may need a higher dose of Bemfola to produce follicles. Pregnancy and breast-feeding Do not use Bemfola if you are pregnant or breast-feeding. Driving and using machines It is not expected that this medicine will affect your ability to drive and use machines. Bemfola contains sodium This medicine contains less than 1 mmol sodium (23 mg) per dose, that is to say essentially “sodiumfree”.

Side Effects

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Serious side effects in women • Lower abdominal pain together with nausea or vomiting may be the symptoms of Ovarian Hyper-Stimulation Syndrome (OHSS). This may indicate that the ovaries over-reacted to the treatment and that large ovarian cysts developed (see also section 2 “Take special care with Bemfola”). This side effect is common (may affect up to 1 in 10 people). • OHSS may become severe with clearly enlarged ovaries, decreased urine production, weight gain, difficulty in breathing and/or possible fluid accumulation in your stomach or chest. This side effect is uncommon (may affect up to 1 in 100 people). • Complications of OHSS such as twisting of ovaries or blood clotting may occur rarely (may affect up to 1 in 1,000 people). • Serious blood clotting complications (thromboembolic events) sometimes independent of OHSS may be found very rarely (may affect up to 1 in 10,000 people). This could cause chest pain, breathlessness, stroke or heart attack (see also section 2 under ‘Blood clotting problems’). Serious side effects in men and women • Allergic reactions such as rash, red skin, hives, swelling of your face with difficulty breathing can sometimes be serious. This side effect is very rare If you notice any of the above-listed side effects you should immediately contact your doctor, who might ask you to stop using Bemfola. 6 Other side effects in women Very common (may affect more than 1 in 10 people): • Sacs of fluid within the ovaries (ovarian cysts) • Headache • Local reactions at the injection site, such as pain, redness, bruising, swelling and/or irritation Common (may affect up to 1 in 10 people): • Abdominal pain • Feeling sick, vomiting, diarrhoea, abdominal cramps and bloating Very rare (may affect up to 1 in 10,000 people): • Allergic reactions such as rash, red skin, hives, swelling of your face with difficulty breathing may occur. These reactions can sometimes be serious. • Your asthma may get worse Other side effects in men Very common (may affect more than 1 in 10 people): • Local reactions at the injection site, such as pain, redness, bruising, swelling and/or irritation Common (may affect up to 1 in 10 people): • Swelling of the veins above and behind the testicles (varicocele). • Breast development, acne or weight gain. Very rare (may affect up to 1 in 10,000 people): • Allergic reactions such as rash, red skin, hives, swelling of your face with difficulty in breathing may occur. These reactions can sometimes be serious. • Your asthma may get worse. Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly (see details below). By reporting side effects you can help provide more information on the safety of this medicine. United Kingdom: Yellow Card Scheme, Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

Ingredients

What Bemfola Injection prefilled pen contains

  • The active substance is follitropin alfa.
  • Bemfola 75 IU/0.125 mL: Each cartridge contains 75 IU (equivalent to 5.5 micrograms) follitropin alfa in 0.125 mL solution.
  • Bemfola 150 IU/0.25 mL: Each cartridge contains 150 IU (equivalent to 11 micrograms) follitropin alfa in 0.25 mL solution.
  • Bemfola 225 IU/0.375 mL: Each cartridge contains 225 IU (equivalent to 16.5 micrograms) follitropin alfa in 0.375 mL solution.
  • Bemfola 300 IU/0.50 mL: Each cartridge contains 300 IU (equivalent to 22 micrograms) follitropin alfa in 0.50 mL solution.
  • Bemfola 450 IU/0.75 mL: Each cartridge contains 450 IU (equivalent to 33 micrograms) follitropin alfa in 0.75 mL solution.
  • Each mL of the solution contains 600 IU (equivalent to 44 micrograms) follitropin alfa.
  • The other ingredients are poloxamer 188, sucrose, methionine, disodium phosphate dihydrate, sodium dihydrogen phosphate dihydrate, phosphoric acid and water for injections.

How to Store

How to store Bemfola

Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date, which is stated on the pen label and carton after EXP. The expiry date refers to the last day of that month. Store in a refrigerator (2°C – 8°C). Do not freeze. Store in the original package in order to protect from light. Within its shelf life, the unopened pen may be stored at or below 25°C for up to 3 months without being refrigerated again and must be discarded if it has not been used after 3 months.

Patient Information leaflet

Click here for the Patient Information leaflet Bemfola Injection prefilled pen

Please read before using the product

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