WHAT ACETAZOLAMIDE 250MG TABLETS ARE AND WHAT THEY ARE USED FOR
Acetazolamide 250mg Tablets (referred to as Acetazolamide 250mg Tablets throughout this leaflet) contain the active substance Acetazolamide. This belongs to a group of medicines known as carbonic anhydrase inhibitors.
Acetazolamide 250mg Tablets are used to treat:
glaucoma (a condition of the eye), by reducing the pressure within the eye.
abnormal retention of fluids (Acetazolamide 250mg Tablets acts as a diuretic)
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
This information will also be on the label.
Acetazolamide 250mg Tablets should be swallowed whole with a drink of water, just before or just after a meal. Do not chew or crush the tablets.
The dose varies from person to person depending on their condition. Your doctor will decide on the most appropriate dose. If you are not sure how many tablets to take or when to take them, ask your doctor or pharmacist.
The recommended dose is
Glaucoma:
Adults: 250mg-1000mg (1-4 tablets) every 24 hours, in divided doses.
Retention of fluid:
Adults: starting dose is 250-375mg (1-1.5 tablets) once daily in the morning. Your doctor will adjust the dose and tell you how often to take your dose.
Epilepsy:
Adults: 250-1000mg daily in divided doses.
Children: the dose will depend on the bodyweight of the child, to be taken in divided doses. Dose should not be more than 750mg (3 tablets) per day.
Before starting and during treatment your doctor may monitor your blood to check that treatment with Acetazolamide 250mg Tablets is suitable for you.
If you take more Acetazolamide 250mg Tablets than you should
Get medical help immediately, either by calling your doctor or going to the nearest hospital casualty department. Take any remaining tablets and this leaflet with you so that the medical staff know exactly what you have taken.
If you forget to take your Acetazolamide 250mg Tablets
You should take it as soon as you remember. However, if this is within two hours of your next dose you should skip the missed tablet and carry on taking the rest of your tablets as usual.
Do not take a double dose to make up for a forgotten dose.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Delivery Options
Delivery options
All deliveries are subject to the availability of the product and product sale conditions been met.
Order & Collect
Free next-day collection from In-Store
UK Delivery
Standard Delivery within the UK £3.50 Delivery time 3-4 days First Class Delivery within the UK £5.90 Delivery time 1-2 days Priority Delivery within the UK £7.10. Next day delivery by 1pm. Order must be placed by 1pm. Priority delivery is only available Monday to Thursday.
Europe Delivery
Standard Delivery within EEC from £12.50 Delivery time up to 5 days depending on the local delivery service within your country. Expedited Delivery within EEC £39.50 Delivery time 2 days. Delivery by DHL, UPS or TNT.
Rest of the World
Standard Delivery Rest of the World from £16.10 Delivery Time 10 – 15 Days Expedited Delivery Rest of the World £55.09 Delivery 5 days. Delivery service by DHL, TNT or UPS
WHAT YOU NEED TO KNOW BEFORE YOU TAKE ACETAZOLAMIDE 250MG TABLETS
Do not take Acetazolamide 250mg Tablets if:
you know you are allergic to sulphonamides, sulphonamide derivatives including acetazolamide or to any of the ingredients in the medicine (listed in Section 6)
you have severe liver problems
you have or have ever had severe kidney problems
you have a particular type of glaucoma known as chronic non congestive angle closure glaucoma (your doctor will be able to advise you)
you have reduced function of the adrenal glands – glands above the kidneys – (also known as Addison’s disease)
you have low blood levels of sodium and/or potassium or high blood levels of chlorine (your doctor will advise you). Speak to your doctor if any of the above applies to you.
Warnings and precautions
Talk to your doctor or pharmacist before taking Acetazolamide 250mg Tablets
you have or have ever had kidney problems such as kidney stones
you have lung problems such as chronic bronchitis or emphysema, which cause difficulty in breathing
you are over the age of 65
a small number of people being treated with anti-epileptics such as Acetazolamide have had thoughts of harming or killing themselves, if at any time you have these thoughts, immediately contact your doctor.
Acetazolamide 250mg Tablets may affect some medical tests. If you visit a hospital or clinic for any medical tests, you should tell the doctor concerned that you are taking Acetazolamide 250mg Tablets.
Other medicines and Acetazolamide 250mg Tablets
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. The effects of any of these medicines may change, particularly if you are taking, or using, any of the following:
medicines for your heart such as cardiac glycosides (e.g. digoxin)
medicines to reduce blood pressure
medicines to thin your blood (e.g. warfarin)
medicines to lower the sugar in your blood (e.g. metformin, gliclazide)
medicines for epilepsy or fits (in particular, phenytoin, primidone or carbamazepine or topiramate)
Drugs which interfere with folic acid, eg methotrexate, pyrimethamine, or trimethoprim
steroids such as prednisolone
aspirin and related medicines, eg salicylic acid or choline salicylate for mouth ulcers
other drugs in the group of medicines called carbonic anhydrase inhibitors (e.g. dorzolamide or brinzolamide which are also used to treat glaucoma)
amphetamines (a stimulant), quinidine (treats an irregular heart beat), methenamine (prevents urine infections) or lithium (treats severe mental problems)
sodium bicarbonate therapy (used to treat high states of acid in your body)
ciclosporin (used to suppress the immune system).
Pregnancy and breast feeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Pregnancy
Acetazolamide 250mg Tablets SHOULD NOT be taken if you are pregnant, think you are pregnant or are planning to become pregnant.
Breast feeding
It may be taken when breast feeding but only on the advice of the doctor.
Driving and using machines
If Acetazolamide 250mg Tablets make you feel drowsy or confused you should not drive or operate machines.
Acetazolamide 250mg Tablets can occasionally cause short-sightedness; if this happens and you feel that you can no longer drive safely, you should stop driving and contact your doctor.
Acetazolamide 250mg Tablets contains sodium
This medicine contains less than 1 mmol sodium (23 mg) per dose, that is to say essentially ‘sodium-free’.
Side Effects
POSSIBLE SIDE EFFECTS
Like all medicines, this medicine can cause side effects, although not everybody gets them.
All medicines can cause allergic reactions although serious allergic reactions are very rare. Any sudden wheeziness, difficulty in breathing, swelling of the eyelids, face or lips, rash or itching (especially affecting your whole body) should be reported to a doctor immediately.
Acetazolamide 250mg Tablets can affect the cells in your blood. This could mean that you are more likely to catch infections and that your blood may not clot properly. If you have a sore throat or fever or you notice bruises or tiny red or purple spots on your skin you should contact your doctor immediately. If your muscles feel weak or you have fits, you should see your doctor immediately.
Acetazolamide 250mg Tablets can affect the liver and kidneys. If you experience pain in your lower back, pain or burning when you pass urine, have difficulty in passing urine, or you stop passing urine, have blood in your urine, pale stools, or if your skin or eyes look slightly yellow, you should contact your doctor. You should also contact your doctor if your stools are black or tarry, or if you notice blood in your stools.
Not known: frequency cannot be estimated from the available data
headache
diarrhoea
feeling or being sick, loss of appetite, thirst, or a metallic taste in the mouth
dizziness, loss of full control of arms or legs
looking flushed
a need to pass urine more often than normal
tiredness or irritability
feeling over-excited
a tingling or numbness in the fingers or toes, or coldness in the extremities.
depression
drowsiness or confusion
a loss of interest in sex
ringing in the ears or difficulty in hearing
temporary short-sightedness which subsides when the dosage is reduced or treatment is stopped.
Rare cases of skin rashes including an increased sensitivity to sunlight have been reported. If you experience any unusual skin rashes, inform your doctor.
If you take Acetazolamide 250mg Tablets for a long time it can occasionally affect the amount of potassium, or sodium in your blood. Your doctor will probably take blood tests to check that this does not happen. You might also experience bone thinning or the risk of kidney stones with long-term therapy. High or low blood sugar levels may occasionally occur.
Contact a doctor immediately if you experience a serious skin reaction: a red, scaly rash with bumps under the skin and blisters (exanthematous pustulosis). The frequency of this side effects is not known (cannot be estimated from the available data).
If any of the side effects becomes serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
Reporting of side effects:
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
Ingredients
What Acetazolamide 250mg Tablets Contain:
The active substance is acetazolamide. Each tablet contains 250mg acetazolamide.
The other ingredients are dicalcium phosphate, corn starch, magnesium stearate, sodium starch glycolate, povidone.
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